Ophthalmology Activities in UGME

Grid focus:Activities
Tagged with: Vision Disorders [C10.597.751.941] (MeSH)
Diplopia [C10.597.751.941.339] (MeSH)
Eye Diseases [C11] (MeSH)
Vision Disorders [C11.966] (MeSH)
Vision Disorders [C23.888.592.763.941] (MeSH)
Diplopia [C23.888.592.763.941.339] (MeSH)
Ocular Motility Disorders [C10.292.562] (MeSH)
Ocular Motility Disorders [C11.590] (MeSH)
Eye [A01.456.505.420] (MeSH)
Eye [A09.371] (MeSH)
Eyelid Diseases [C11.338] (MeSH)
Eyelids [A01.456.505.420.504] (MeSH)
Ophthalmic Solutions [D26.255.775.645] (MeSH)
Ophthalmic Solutions [D26.776.708.645] (MeSH)
Ophthalmic Solutions [D27.720.280.775.645] (MeSH)
Color Vision Defects [C23.888.592.763.941.256] (MeSH)
Optic Nerve [A08.800.800.120.680] (MeSH)
Optic Disk [A08.800.800.120.680.660] (MeSH)
Optic Nerve Diseases [C10.292.700] (MeSH)
Optic Neuritis [C10.292.700.550] (MeSH)
Optic Nerve Diseases [C11.640] (MeSH)
Optic Neuritis [C11.640.576] (MeSH)
Pupil Disorders [C10.597.690] (MeSH)
Pupil Disorders [C11.710] (MeSH)
Pupil Disorders [C23.888.592.708] (MeSH)
Vision, Low [C10.597.751.941.905] (MeSH)
Vision, Low [C23.888.592.763.941.848] (MeSH)
Conjunctival Diseases [C11.187] (MeSH)
Eye Hemorrhage [C11.290] (MeSH)
Retinal Diseases [C11.768] (MeSH)
Eye Hemorrhage [C23.550.414.756] (MeSH)
Retinal Hemorrhage [C23.550.414.756.775] (MeSH)
Eye Neoplasms [C11.319] (MeSH)
Eye Abnormalities [C11.250] (MeSH)
Orbital Diseases [C11.675] (MeSH)
Eye Diseases, Hereditary [C11.270] (MeSH)
Optics [H01.671.606] (MeSH)
Ophthalmology (Discipline)
Diplopia (MCC Presentations)
Eye Redness (MCC Presentations)
Strabismus and/or Amblyopia (MCC Presentations)
Acute Visual Disturbance/Loss (MCC Presentations)
Chronic Visual Disturbance/Loss (MCC Presentations)
Uveal Diseases [C11.941] (MeSH)
Eye Movements [G11.427.590.530.140] (MeSH)
Neuromyelitis Optica [C10.292.700.550.500] (MeSH)
Optic Chiasm [A08.800.800.120.680.600] (MeSH)
Retinal Neurons [A09.371.729.831] (MeSH)
Retinal Cone Photoreceptor Cells [A09.371.729.831.625.670.100] (MeSH)
Retinal Rod Photoreceptor Cells [A09.371.729.831.625.670.650] (MeSH)
Diagnostic Techniques, Ophthalmological [E01.370.380] (MeSH)
Ophthalmoscopy [E01.370.380.560] (MeSH)
Eye Neoplasms [C04.588.364] (MeSH)
Reflex, Pupillary [E01.370.376.550.650.690] (MeSH)
Retinal Neoplasms [C04.588.364.818] (MeSH)
Graves Ophthalmopathy [C11.270.842] (MeSH)
Ocular Physiological Phenomena [G14] (MeSH)
Ocular Physiological Processes [G14.640] (MeSH)
Vision, Ocular [G14.640.816] (MeSH)
Pupil [A09.371.894.513.780] (MeSH)
Vision, Ocular [F02.830.816.964] (MeSH)
Refractive Errors [C11.744] (MeSH)
Myopia [C11.744.636] (MeSH)
Astigmatism [C11.744.212] (MeSH)
Retinal Degeneration [C11.768.585] (MeSH)
Ophthalmological examination: tonometry, fluorescein, use of slit lamp (AFMC National Clinical Skills)
Eye Infections [C01.375] (MeSH)
Ophthalmoscopes [E07.230.540] (MeSH)
Vision Tests [E01.370.380.850] (MeSH)
Eye Injuries [C11.297] (MeSH)
Eye Manifestations [C11.300] (MeSH)
Eye Pain [C11.300.500] (MeSH)
Orbital Cellulitis [C11.675.387] (MeSH)
Tag method: Match any
Exclusions: Archived (Archived)
= most relevant
Displaying 24 records
Activities Linked ObjectivesCurriculum BlockMCC Presentations

Clinical Skills Sessions: Head and Neck Exam: Practice Case - Sore Throat

Part 1, Medical Foundation 1, Cardiology, Week 4

Objective: To discuss and to practice the Head and Neck history and physical exam, with a focus on the oropharyngeal exam. Pro-Comp Connection: Poverty - the disproportionate burden of Rheumatic Heart Disease on marginalized populations.

Part 1
Medical Foundation 1
Cardiology
Week 4
Neck Pain
Neck Mass, Goiter, Thyroid Disease
Sore Throat and/or Rhinorrhea

Tutorial: Adam Pajek MF3 Endocrinology

Part 3, Medical Foundation 3, Endocrinology, Week 2

A 40-year old man, Adam Pajek, was seen in a walk-in clinic complaining of palpitations, heat intolerance (felt hot when others were comfortable or cold), sweating, anxiety, weight loss, fatigue, and sleeplessness for two months. He reports that his sister has a hypothyroid problem for which she takes Eltroxin pills.

General Objectives
Recognize the pituitary as the central control gland of the body.
Outline the synthesis and secretion of thyroid hormones, the types of thyroid hormone and the feedback loops governing interactions between the pituitary gland and the thyroid gland.
Explain the physiological function of thyroid hormone, including its effects on basal metabolic rate.
Explain the laboratory abnormalities and clinical manifestations seen in thyroid dysfunction.
Describe the treatment of thyroid disease.
Global Objectives
Upon completion of this problem, students will describe the role of thyroid hormones in energy metabolism.
Part 3
Medical Foundation 3
Endocrinology
Week 2
Fatigue
Neck Mass, Goiter, Thyroid Disease
Palpitations
Anxiety
Sleep-Wake Disorders
Weight Loss / Eating Disorders / Anorexia

Tutorial: Calvin Shin MF3 Endocrinology

Part 3, Medical Foundation 3, Endocrinology, Week 2

Dr. Jones has been following Calvin Shin for several years for obstructive sleep apnea. He had been doing well with reduced symptoms of daytime sleepiness since he had been using his CPAP machine. Dr. Jones was reviewing John's chart in his clinic. He missed his appointment several months ago but booked an urgent appointment through his family doctor. Calvin explains that he thinks his tongue, nose and lips have been getting thicker. He also states that he seems to be sweating and his skin feels thicker and oilier than it used to.

General Objectives
Recognize the pituitary as the central control gland of the body.
List the hormones produced by the pituitary and explain their effects on body function.
Describe the most common pathologies associated with pituitary hormone systems including acromegaly and hyperprolactinemia.
Global Objectives
Upon completion of this problem, students will be able to describe normal pituitary structure and function and compare with the pathologic state of growth hormone excess.
Part 3
Medical Foundation 3
Endocrinology
Week 2
Dyspnea
Fatigue
Headache
Erectile Dysfunction
Oral Conditions
Numbness / Tingling / Altered Sensation
Stature Abnormal (Tall Stature / Short Stature)
Hypertension
Chronic Visual Disturbance/Loss

Tutorial: Jane Young MF4 MSK

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 3

Jane Young is a 3 1/2 year-old girl, brought to the Pediatric Medicine Clinic by her mother. For the past 10 days, her right knee has been swollen and stiff. There was no preceding trauma. She seems to have most symptoms in the morning, getting better when she is up and about playing. She seems to have less energy since the swelling was first noted. Her mother has been giving her children's Tylenol but has not noticed any improvement in her symptoms. Her mother thinks her ankles are also "puffy" at times. On examination, Jane appears well, afebrile and is on the 50th percentile for height and weight. No fever or skin rashes. Cardiovascular, respiratory and abdominal examinations unremarkable. Right knee is swollen, warm and effused and Jane stands with this knee slightly flexed. There are mild effusions of both ankles which are also slightly swollen. The pediatrician decides to order a few investigations. Baseline CBC, renal and liver function is unremarkable. ESR moderately elevated at 30. Rheumatoid Factor is negative, but Antinuclear Antibody (ANA) is positive at 1:160.

General Objectives
Describe the scope and multi-system nature of many autoimmune musculoskeletal diseases.
Global Objectives
Upon completion of this problem, students will be able to explain key concepts in Juvenile Idiopathic Arthritis (JIA).
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 3
Limp in Children
Fatigue
Generalized Edema
Oligoarthralgia (Pain in One to Four Joints)

Tutorial: Theodore McIntyre MF4 MSK

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 4

Mr. McIntyre, a 69 year old man, has developed a new onset right-sided headache for the last 5 days. He has some pain when he chews his food and has been feeling increasingly fatigued. He has had stiffness in his shoulders and his hips so much so that it takes him at least an hour to get up and move around first thing in the morning. He has started to develop some double vision. He has tenderness when he combs his hair on the right side of his temple. Physical exam reveals a BP of 120/70 (right arm) and 126/68 (left arm), HR 75/min, temp 37. He has tenderness along his R temporal region and the R temporal artery feels thickened.

Global Objectives
Upon completion of this case, students will be able to describe Giant Cell Arteritis as one type of vasculitis.
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 4
Diplopia
Fatigue
Headache
Oral Conditions
Acute Visual Disturbance/Loss
Oligoarthralgia (Pain in One to Four Joints)

Tutorial: Neil Wartson (Part 2) MF4 Neuro

Part 4, Medical Foundation 4, Neuroscience, Week 1

Neil Wartson is brought back to his family doctor 6 months later. The MRI has still not been performed, but the audiology testing confirmed severe sensorineural hearing loss on the right. Upon entering the office, Neil’s mother is very upset and agitated. Over the last month, she has noticed that Neil has become clumsier and is falling frequently. He also has started to rub his eye a lot and complains that things are “fuzzy”. She also reports that, since the last visit, Neil’s father has been investigated for his hearing loss. He is currently being worked up for Neurofibromatosis Type II. Neil’s mother has looked this up on the internet and is convinced that Neil has this as well.

General Objectives
Identify major structures in the brainstem and recall their basic functions.
Describe some basic concepts surrounding brain tumor development.
Global Objectives
Upon completion of this problem, students should be able to recognize the basic anatomy and function of some of the structures of the brainstem.
Part 4
Medical Foundation 4
Neuroscience
Week 1
Falls
Genetic Concerns
Acute Visual Disturbance/Loss

Tutorial: Mandy Wallsmith (Part 2) MF4 Neurology

Part 4, Medical Foundation 4, Neuroscience, Week 1

Six months after her previous presentation of transverse myelitis, from which she completely recovered, Mandy Wallsmith returns with complaints of bilateral visual loss (worse on the right). The problem started two days ago with pain in and behind her right eye, worse when she would look to the left or right. Yesterday, she began to notice that she wasn't seeing well out of her right eye. Today her vision seems worse, although the pain is a little better. On examination, her visual acuity is found to be 20/80 in the left eye (OS) and 20/400 in the right eye (OD). Visual field appears to be normal in the left eye, but she can only detect hand motion (not finger counting) in all quadrants with the right eye. She finds that colours look less vivid with her right eye - especially red, which looks "kind of gray".

General Objectives
Recognize the anatomy and physiology of the eye; cones, rods, eye ball, optic nerve.
Describe the anatomy of optic nerve and optic chiasm.
Explain the basic pathophysiology and common clinical presentations of multiple sclerosis.
Global Objectives
Upon completion of this problem, students should be able to discuss the anatomy and physiology of the eye and optic nerves.
Part 4
Medical Foundation 4
Neuroscience
Week 1
Acute Visual Disturbance/Loss

Large Group Session: Intro to Neurology subunit and Intro to Neurosciences

Part 4, Medical Foundation 4, Neuroscience, Week 1

How much Neuro do you need to know? What do residency program directors expect? Weekly themes: Week 1:Muscle, NMJ, Nerve. Week 2: spinal cord, brainstem. Week 3: Basal Ganglia, Limbic system. Week 4: Cerebral cortex. Muscle. Localization. Neuromuscular junction. Nerve. Resting potential. Post-synaptic potentials. Anterior horn. Central vs. peripheral nervous system. Spinal cord. Brainstem. Cerebellum. Limbic system. Basal Ganglia. Cerebral cortex.

Part 4
Medical Foundation 4
Neuroscience
Week 1

Tutorial: Ivan Nettar MF4 Neurology

Part 4, Medical Foundation 4, Neuroscience, Week 2

Ivan is a 68 year old man who has enjoyed excellent health in the past. His only medication is hydrochlorothiazide for mild hypertension. For the past few weeks he noticed that by the end of the day he had difficulty focusing his eyes and keeping them open. He decided to see his family physician when the other day his vision became double. On the day of the visit, Ivan was feeling even worse. His double vision was present shortly after lunch and he felt generally weak. On observation, it was clear that Ivan had a right-sided ptosis. He kept closing one eye and then the other, complaining that otherwise his vision was double. His voice seemed mildly hoarse. Blood pressure was normal at 135/80. General physical examination of the heart, lungs, and abdomen was normal. Neurological examination showed that the pupils were equal and reactive. A prominent ptosis was present on the right. The extra ocular movements were abnormal with dysconjugate gaze present intermittently and not consistently on lateral, upward, and downward gaze. The other cranial nerves were normal. Tone was normal in the limbs. He had some difficulty holding up his arms in the air for more than a couple of minutes. He had some difficulty doing more that 5 deep knee bends. Sensation was normal and the reflexes were all present and symmetric. The plantar responses were down going. You ask Ivan to close his eyes and rest them for a few minutes while you make some notes. You ask him then to open his eyes and temporarily the double vision is much better and the ptosis is almost gone! A referral is made to the neurologist on call. She asks that you send Ivan to the emergency room so that she can perform a tensilon test to confirm the diagnosis.

General Objectives
Identify the anatomy and describe the physiology of the neuromuscular junction.
Global Objectives
Upon completion of this problem, students should be able to describe the normal function of the neuromuscular junction.
Part 4
Medical Foundation 4
Neuroscience
Week 2
Diplopia
Language and Speech Disorders
Weakness (not caused by Cerebrovascular Accident)

Clinical Skills Sessions: Neurology Exam: Practice Cases – Vertigo, Headache

Part 4, Medical Foundation 4, Neuroscience, Week 2

Discuss and practice the components of the history and physical exam for a patient presenting with vertigo. Discuss and practice the components of the history and physical exam for a patient presenting with headache.

Part 4
Medical Foundation 4
Neuroscience
Week 2
Dizziness, Vertigo
Headache
Strabismus and/or Amblyopia

Anatomy Lectures: Motor Pathways

Part 4, Medical Foundation 4, Neuroscience, Week 2

Parts of the central nervous system. Cerebral cortex: thinking, memory, voluntary motor movements sensory perception. White matter vs. grey matter. Superficial features of the cerebrum: fissures, sulci and gyri. Lateralization of function in the cerebral cortex. Frontal lobe. Parietal lobe. Occipital lobe. Temporal lobe. Spinal cord reflexes. Corticospinal tracts. Upper and lower motor neuron lesions. Corticobulbar tracts. Coordination of movement. Influence of Basal ganglia.

Part 4
Medical Foundation 4
Neuroscience
Week 2

Tutorial: Adrian Scholtz Part 2

Part 5, Integration Foundation, Maternal Health Risks/Aging-Related Care, Week 4

Adrian was admitted to the ICU 24 hours ago. Since that time, additional investigations and bloodwork has been ordered. Adrian underwent a CT chest to rule out pulmonary pathology and septic embolic in the lungs are confirmed. Blood cultures are positive for Methicillin-resistant Staphylococcus aureus (MSSA). After an infectious disease consult, Adrian is started on IV Ancef. The Cardiology team led by Dr. Sibbald and the Cardiac Surgery team led by Dr. Semelhago agrees that the patient requires a repeat heart valve replacement. In addition, the nurses observe Adrian to appear to be volume overloaded with worsening swelling. Despite copious IV fluids, Adrian is not making much urine (<200mL/day). A nasogastric tube was inserted for methadone administration. The nurse and dietician are requesting consideration for total parenteral nutrition based on recent laboratory results demonstrating malnutrition and hypoproteinemia. Ophthalmology is consulted for concerns of septic emboli following completion of an MRI of the brain. Nephrology consulted and believes dialysis may help the patient, but it is not the definitive treatment. They will only start dialysis if the patient is under consideration for repeat heart valve surgery.

Global Objectives
Upon completion of this problem, students will be able to demonstrate the integration of cardiac, respiratory, hematology and renal core concepts in critical management of a patient with complex sepsis including ethical issues with social issues and chronic drug use.
Part 5
Integration Foundation
Maternal Health Risks/Aging-Related Care
Week 4
Substance Withdrawal
Substance Use or Addictive Disorders
Acute Kidney Injury (Anuria or Oliguria)

e-Learning Module: Red Eye

Clerkship, Emergency Medicine Rotation

In this module you'll learn about the approach to the red eye.

Clerkship Objectives
Eye pain (including red eye)
Clerkship
Emergency Medicine Rotation
Eye Redness

Clinical Exposure: EM Medical Expert (presenting problems)

Clerkship, Emergency Medicine Rotation

Demonstrate an approach to patients presenting to the ED with the following problems listed below (including basic differential diagnosis, initial investigations, and initial treatments)

Clerkship Objectives
Chest pain
Shortness of breath
Altered level of consciousness - including the recognition and management of acute stroke
Anaphylaxis / severe allergic reaction
Abdominal pain
Loss of consciousness (syncope)
Shock - Recognize shock and predict underlying etiology (distributive, cardiogenic, hypovolemic, obstructive).
Seizure
Cardiorespiratory arrest
Headache
Minor trauma / MSK injuries (including fracture / dislocation/ sprain). Explain the ABCDE approach to major and minor trauma, identify resuscitative priorities and recognize injuries which require acute management.
Abnormal behavior (psychosis, delirium, intoxication, violence).
Head injury - minor
Fever
Dizziness / vertigo
Cardiac dysrhythmias. Synthesize ACLS (Advanced Cardiovascular Life Support) algorithms, recognize unstable ACLS states and use ACLS algorithms to guide treatment.
Vaginal bleeding - pregnant
Poisoning
Burns - minor / major
Urinary symptoms
Neck and back pain
Eye pain (including red eye)
Clerkship
Emergency Medicine Rotation
Lower urinary tract symptoms
Allergic Reactions and Atopy
Back Pain and Related Symptoms (e.g., Sciatica)
Neck Pain
Burns
Cardiac Arrest
Chest Pain
Dizziness, Vertigo
Dyspnea
Eye Redness
Headache
Poisoning
Early Pregnancy Loss / Spontaneous Abortion
Psychosis
Seizures / Epilepsy
Syncope and Pre-Syncope
Trauma
Vaginal Bleeding, Excessive/Irregular/Abnormal
Abnormal Heart Sounds and Murmurs
Acute Abdominal Pain
Delirium
Dysuria, Urinary Frequency and Urgency, and/or Pyuria
Fever in the Immune Compromised Host / Recurrent Fever
Hypotension/Shock
Abdominal Pain (Children)
Bone or Joint Injury
Chronic Abdominal Pain
Fever and Hyperthermia
Head Trauma / Brain Death / Transplant Donations

Clinical Exposure: Ophthalmology

Clerkship, Family Medicine Rotation

Clerkship Objectives
Red eye
Clerkship
Family Medicine Rotation
Eye Redness

Tutorial: Ophthalmology

Clerkship, Family Medicine Rotation

Clerkship Objectives
Red eye
Clerkship
Family Medicine Rotation
Strabismus and/or Amblyopia
Acute Visual Disturbance/Loss
Chronic Visual Disturbance/Loss

Clinical Exposure: Cellulitis

Clerkship, Internal Medicine Rotation

Clerkship Objectives
Cellulitis
Clerkship
Internal Medicine Rotation
Eye Redness
Skin and Integument Conditions
Localized Edema

Clinical Exposure: Cerebrovascular disease

Clerkship, Internal Medicine Rotation

Clerkship Objectives
Cerebrovascular disease (including stroke)
Clerkship
Internal Medicine Rotation
Cerebrovascular Accident and Transient Ischemic Attack (Stroke)
Acute Visual Disturbance/Loss
Hypertension
Clerkship Objectives
Perform red reflex and cover-uncover test
Essential Clinical Experience
Fundoscopy
Pediatrics Rotation

Large Group Session: Neurosurgery

Clerkship, Surgery Rotation

Epidural hematoma. Subdural hematoma. Cerebral Contusion. Basal Skull Fractures. Intracranial Hemorrhage. Diffuse Axonal Injury. Pathophysiology of supratentorial brain herniation. Grading of consciousness - Glasgow Coma Scale (GCS). Clinical classification of Traumatic Brain Injury (TBI). ICP = Intracranial Pressure. Munro-Kellie doctrine. Brain tumor. Intracerebral hemorrhage. Management of severe pediatric TBI.

Clerkship Objectives
Describe the physiology of intracerebral pressure (ICP) and cerebral perfusion pressure (CPP), including the effects of blood pressure, ventilatory status, and fluid balance on ICP and CPP.
Recognize the Cushing reflex and its clinical importance (brain herniation).
Describe the signs, etiology and treatment of intracranial hemorrhage (subarachnoid hemorrhage and intracerebral hemorrhage).
Describe the relative incidence and location of the most common brain tumors, their clinical manifestations, their diagnosis, and general treatment strategies.
Differentiate TIA, RIND, and CVA.
Describe the presentation and management of hydrocephalus. Compare and contrast adult and pediatric hydrocephalus.
Students will understand the importance of early diagnosis and treatment in subarachnoid hemorrhage and epidural hematomas.
Clerkship
Surgery Rotation
Headache
Acute Visual Disturbance/Loss
Head Trauma / Brain Death / Transplant Donations

Large Group Session: Ophthalmology

Clerkship, Surgery Rotation

Approach to the Red Eye. Common Retinal Problems. Urgent diagnosis of Eye problems: Diabetes mellitus; Temporal arteritis; Thyroid orbitopathy; Optic neuritis; Papilledema.

Clerkship Objectives
Red eye: Traumatic; Infectious; Inflammatory; Chronic
Common retinal problems
Cataracts
Pterygium
Chalazion
Clerkship
Surgery Rotation
Eye Redness
Acute Visual Disturbance/Loss
Chronic Visual Disturbance/Loss

Concept Integration and Review: Microbiology and Infectious Disease

Post-clerkship, Concept Integration and Review

Infectious diseases. Transmission. Gram Stain. Microbiology. Infections head to toe.

Post-clerkship
Concept Integration and Review
Blood in Sputum (Hemoptysis)
Cough
Dyspnea
Ear Pain
Eye Redness
Pleural Effusion
Sore Throat and/or Rhinorrhea
Vaginal Discharge / Vulvar Pruritis / STI
Vomiting and/or Nausea
Dysuria, Urinary Frequency and Urgency, and/or Pyuria
Localized Edema
Abdominal Pain (Children)
Fever and Hyperthermia

Concept Integration and Review: Endocrinology

Post-clerkship, Concept Integration and Review, Week 4

Thyroid disorders: Hypothyroidism; Thyrotoxicosis (Graves, toxic nodule, thyroiditis); Thyroid Nodules. Pituitary Disorders: Pituitary disorder manifests clinically in 3 ways: Hyperfunction: too much hormones; Hypofunction: too little hormones; Local mass effects; Acromegalia. Posterior Pituitary dysfunction: ADH. Adrenal Disorders.

Post-clerkship
Concept Integration and Review
Week 4
Diplopia
Abnormal, Serum Lipids
Neck Mass, Goiter, Thyroid Disease
Stature Abnormal (Tall Stature / Short Stature)
Diabetes Mellitus
Hyperkalemia
Chronic Visual Disturbance/Loss
Hyponatremia
Calcium disorders

Clinical Skills Sessions: Review of diabetic exam

Observation of a student(s) taking history from a patient with diabetes (polyuria, polydipsia, fatigue, etc.) and performing appropriate physical examination. JAMA article review: Does this patient have diabetic neuropathy?

Fatigue
Diabetes Mellitus
Chronic Visual Disturbance/Loss
Polyuria and/or Polydipsia
Weight Loss / Eating Disorders / Anorexia