Activities in ugme tagged with Immunology

Grid focus:Activities
Tagged with: Autoimmune Diseases of the Nervous System [C10.114] (MeSH)
Immune System Diseases [C20] (MeSH)
Autoimmune Diseases [C20.111] (MeSH)
Immune System [A15.382] (MeSH)
Bone Marrow [A15.382.216] (MeSH)
Leukocytes [A11.118.637] (MeSH)
Leukocytes [A15.145.229.637] (MeSH)
Leukocytes [A15.382.490] (MeSH)
Bone Marrow Examination [E01.370.225.625.135] (MeSH)
Immunotherapy [E02.095.520] (MeSH)
Immunoproliferative Disorders [C20.683] (MeSH)
Immunoproteins [D12.776.124.486] (MeSH)
Immunoglobulins [D12.776.124.486.485] (MeSH)
Immunoglobulins [D12.776.124.790.651] (MeSH)
Immunoglobulins [D12.776.377.715.548] (MeSH)
Leukocytes, Mononuclear [A11.118.637.555] (MeSH)
Leukocytes, Mononuclear [A15.145.229.637.555] (MeSH)
Leukocytes, Mononuclear [A15.382.490.555] (MeSH)
Immunologic Deficiency Syndromes [C20.673] (MeSH)
Acquired Immunodeficiency Syndrome [C20.673.480.040] (MeSH)
Allergy and Immunology (Discipline)
Immunology (Basic Sciences)
Immunization (MCC Presentations)
Fever in the Immune Compromised Host / Recurrent Fever (MCC Presentations)
Hematopoietic System [A15.378] (MeSH)
Bone Marrow Cells [A15.378.316] (MeSH)
Bone Marrow Diseases [C15.378.190] (MeSH)
Antigens [D23.050] (MeSH)
Antigens, Surface [D23.050.301] (MeSH)
Histocompatibility Antigens [D23.050.301.500] (MeSH)
Histocompatibility Antigens Class I [D23.050.301.500.400] (MeSH)
HLA-B Antigens [D23.050.301.500.400.380] (MeSH)
Immunologic Tests [E01.370.225.812] (MeSH)
Immunohistochemistry [E01.370.225.500.607.512] (MeSH)
Immune System Phenomena [G12] (MeSH)
Immunity [G12.450] (MeSH)
Immunity, Mucosal [G12.450.573] (MeSH)
Immunization [E02.095.520.400] (MeSH)
Immunotherapy, Active [E02.095.520.400.530] (MeSH)
Immunity, Herd [G12.450.562] (MeSH)
Antigens, Differentiation [D23.101.100] (MeSH)
Antigens, CD [D23.101.100.110] (MeSH)
Acquired Immunodeficiency Syndrome [C02.782.815.616.400.040] (MeSH)
Immunization, Passive [E02.095.520.400.330] (MeSH)
Immunotherapy, Adoptive [E02.095.520.400.330.050.400] (MeSH)
Antigens, Neoplasm [D23.050.285] (MeSH)
Antibody-Producing Cells [A11.063] (MeSH)
Immune System Processes [G12.425] (MeSH)
Antibody Formation [G12.425.071] (MeSH)
Prostate-Specific Antigen [D23.101.840.625] (MeSH)
Immunity, Innate [G12.450.575] (MeSH)
Adaptive Immunity [G12.450.050] (MeSH)
Immunity, Active [G12.450.050.370] (MeSH)
Immunologic Memory [G12.450.050.500] (MeSH)
Immunity, Cellular [G12.450.050.400] (MeSH)
Immunity, Humoral [G12.450.050.420] (MeSH)
Receptors, Immunologic [D12.776.543.750.705] (MeSH)
Immunogenetic Phenomena [G12.500] (MeSH)
Antigen Presentation [G12.425.107] (MeSH)
Antigen-Presenting Cells [A11.066] (MeSH)
Cytotoxicity, Immunologic [G12.425.270] (MeSH)
Severe Combined Immunodeficiency [C20.673.815] (MeSH)
Rh Isoimmunization [C15.378.120.780] (MeSH)
Demyelinating Autoimmune Diseases, CNS [C10.314.350] (MeSH)
Immunoglobulin Isotypes [D12.776.124.790.651.114.619] (MeSH)
Immunoglobulin E [D12.776.124.790.651.114.619.312] (MeSH)
Immunomodulation [E02.095.465] (MeSH)
Immunotherapy [E02.095.465.425] (MeSH)
Immunosuppression [E02.095.465.425.450] (MeSH)
Autoimmunity [G12.450.192] (MeSH)
Immunocompromised Host [G12.470] (MeSH)
Immunization [N06.850.780.680.310] (MeSH)
Phagocytes [A15.382.680] (MeSH)
Immunomodulation [G12.425.746] (MeSH)
Immunologic Techniques [E05.478] (MeSH)
Immunization [E05.478.550] (MeSH)
Immunization Schedule [E05.478.550.545] (MeSH)
Antineoplastic Agents, Immunological [D27.505.954.248.384] (MeSH)
Receptors, Antigen [D12.776.543.750.705.816] (MeSH)
Receptors, Antigen, T-Cell [D12.776.543.750.705.816.824] (MeSH)
Receptors, Antigen, B-Cell [D12.776.543.750.705.816.821] (MeSH)
Common Variable Immunodeficiency [C20.673.330] (MeSH)
Transplantation Immunology [G12.875] (MeSH)
Immunology (Longitudinal Discipline)
Tag method: Match any
Exclusions: Archived (Archived)
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Displaying 74 records
Activities Linked ObjectivesCurriculum BlockMCC Presentations

Tutorial: Luke Tomczak MF1 Respirology

Part 1, Medical Foundation 1, Respirology, Week 1

Luke, a 47 year old gentleman with a history of chronic alcoholism and poor eating habits, goes to the ER with a complaint of chest pain. He smokes two packs of cigarettes daily. He has not been feeling well for over one week due to an upper respiratory infection. Two days ago he developed a fever, chills and a sharp pain over his right chest that is worse when he breathes in. Luke had a dry cough initially, but today he has coughed up rusty sputum with some blood in it. Although Luke is not normally short of breath, he has had difficulty climbing the stairs to the office because of breathlessness.

General Objectives
Describe the acute response of the respiratory system to inhaled material.
Describe the response of the respiratory system to chronic inflammation.
Describe the main respiratory pathogens in community and hospital-acquired lung infections along with their major distinguishing features.
Global Objectives
Upon completion of this problem, students should be able to describe the mechanism of hypoxia in alveolar inflammation.
Part 1
Medical Foundation 1
Respirology
Week 1
Blood in Sputum (Hemoptysis)
Chest Pain
Cough
Cyanosis, Hypoxia
Dyspnea
Pleural Effusion
Concepts of Health and Its Determinants
Fever and Hyperthermia

Tutorial: Thomas Gagnon MF1 Respirology

Part 1, Medical Foundation 1, Respirology, Week 2

Thomas Gagnon, a 12 year old boy diagnosed with asthma 1 year ago, traditionally experienced minimal respiratory symptoms. In the past, he had used inhaled salbutamol sparingly, generally during soccer games, with excellent therapeutic effect. During a late September soccer game being held in a rural area, Thomas developed sudden onset dyspnea, wheeze, and chest discomfort. Earlier in the day he had visited with family members who smoke and have three pet cats. His symptoms were mostly relieved with repeated doses of salbutamol. He awakes the following night with ongoing symptoms that are not responsive to inhaled salbutamol, despite frequent dosing. His parents are alarmed and take him to the emergency department.

General Objectives
Describe the factors that determine airway calibre (upper and lower), including autonomic control and chemical mediators of inflammation.
Explain the basic pathophysiology of the diseases which result in airway obstruction (upper and lower airway).
Explain the effects of airflow obstruction on the respiratory tract, lung mechanics and gas exchange. Use this knowledge to explain the symptoms and signs with which the patient with lower or upper airway obstruction presents.
Explain the assessment of airflow obstruction using diagnostic tests.
Develop a mechanism-based approach to management of airflow obstruction.
Describe how the mechanics of breathing are disturbed in examples of obstructive and non-obstructive (“restrictive”) diseases.
Global Objectives
Upon completion of this problem, students should be able to describe the factors that influence airway luminal diameter, and the key aspects of allergic mediated inflammation.
Part 1
Medical Foundation 1
Respirology
Week 2
Chest Pain
Cough
Dyspnea
Acid-Base Abnormalities
Pediatric Respiratory Distress

Tutorial: Teresa J. MF1 Respirology

Part 1, Medical Foundation 1, Respirology, Week 3

Teresa, a 65-year-old woman, is brought to the emergency room by a friend who was unable to arouse Teresa completely. Her friend reports that Teresa had been unwell for three days with persistent vomiting. In the emergency room, Teresa is only semi-rousable. Her pulse is 130 and blood pressure is 100/70. Her breathing is rapid and deep. Teresa’s medical record indicates a history of poorly controlled diabetes and premature coronary artery disease, with a prior myocardial infarction at age 49. She is described as “treatment non-compliant” and is noted to have a “difficult psychosocial situation”.

General Objectives
Explain the relationship between alveolar ventilation, gas exchange and the acid-base balance in the blood.
Explain the impact of hyper- or hypoventilation on arterial blood gas balance.
Explain the basic pathophysiology of the diseases which result in disturbances in gas exchange.
Discuss the concept underlying Adult Respiratory Distress Syndrome (ARDS) and some of its most common causes.
Global Objectives
Upon completion of this problem, students should be able to explain the role of the alveolar-capillary membrane in gas exchange.
Part 1
Medical Foundation 1
Respirology
Week 3
Cyanosis, Hypoxia
Acid-Base Abnormalities
Pleural Effusion
Vomiting and/or Nausea

Tutorial: Arthur N. MF1 Respirology

Part 1, Medical Foundation 1, Respirology, Week 3

Arthur N., a 64-year-old gentleman, presents to his family physician because he is noticing increasing difficulty walking because of breathlessness. He states that he cannot put a finger on when it first began "except that he is aware that he was not as fit" as he should be. Arthur has always enjoyed his walking. However, over the last six months, he has noticed that any incline will make him breathless to the point that friends will remark on it, and he simply has to stop walking. In addition, climbing stairs has become quite difficult. He remarks that he has not been breathless at rest, nor at night-time. He has not noticed any swelling of his ankles. Arthur states that he smoked lightly about twenty years ago. His occupational history is unremarkable and there is no history of heart disease.

General Objectives
Identify the lung volumes that can be measured during spirometry and full pulmonary function.
Describe the response of the respiratory system to chronic inflammation.
Explain the effect of the distribution of ventilation and perfusion within the lungs on gas exchange, and what is meant by the terms "shunt" and "dead space"
Recognize the importance of occupational exposures leading to respiratory disease.
Explain the basic pathophysiology of the diseases which result in disturbances in gas exchange.
Conduct an appropriate respiratory history, including medication and occupation history.
Describe how the mechanics of breathing are disturbed in examples of obstructive and non-obstructive (“restrictive”) diseases.
Global Objectives
Upon completion of this problem, students should be able to explain how disruption of the alveolar capillary membrane affects gas transfer in the lung.
Part 1
Medical Foundation 1
Respirology
Week 3
Cyanosis, Hypoxia
Dyspnea
Environment

Tutorial: Novak B Part 1 MF1 Cardiovascular

Part 1, Medical Foundation 1, Cardiology, Week 3

Novak B. is a 55-year-old man with a history of type 2 diabetes mellitus, hypertension and hyperlipidemia. He presents himself at your office because he has been experiencing chest pain for several days, but has been reluctant to come to the office. He first noted it 6 weeks ago while shoveling snow. The discomfort was mid-sternal and radiated to his jaw. It resolved with rest. Since then, he has noted 3 similar episodes each occurring while climbing the 2 flights of stairs from his basement to the bedroom. Upon further questioning, he also tells you that he feels cramps in both of his calves whenever he walks for more than 500 meters. If he stops walking, his symptoms resolve within 2-3 minutes. On examination, he is mildly obese. His pedal artery and posterior tibial artery pulses are significantly decreased in volume bilaterally. The remainder of the examination is normal. You diagnose him with angina and prescribe aspirin, a beta-blocker, a statin and nitroglycerin. You also make a referral to a dietician.

General Objectives
Describe the pathophysiology of atherosclerosis.
Recognize the factors that promote coronary atherosclerosis ("risk factors").
Explain the general principles of myocardial cell metabolism and know the determinants of myocardial oxygen consumption - MVO2
Recognize the structure of myocardial cells and the mechanism by which they contract.
Describe the pathophysiology behind common clinical presentations of atherosclerotic disease including stable angina, unstable angina and myocardial infarction (including complications of acute myocardial infarction).
Recognize non-coronary atherosclerosis, and what clinical syndromes that may result as a consequence of atherosclerotic involvement of the peripheral vascular system.
Global Objectives
Upon completion of this problem, students should be able to describe the pathophysiology of atherosclerosis and its relationship to cardiovascular disease.
Part 1
Medical Foundation 1
Cardiology
Week 3
Chest Pain

Tutorial: Amanda VP MF1 Cardiovascular

Part 1, Medical Foundation 1, Cardiology, Week 4

Amanda VP. is a 44-year-old Russian immigrant whom you first meet at family health team where you are completing your core training as a family medicine resident. Amanda presents to the clinic because she’s had a two-week history of fevers, chills, malaise and shortness of breath on exertion. She became particularly concerned earlier today when she experienced a brief episode of left arm weakness that lasted for approximately 5 minutes and then completely resolved. Amanda, one of four children, grew up in the former Soviet Union, in a poor household with her extended family (cousins, aunt and uncle, and grandparents). Amanda VP.’s short stature makes you wonder if she was malnourished as a child and if so, what other effects this may have had on her health. Her past medical history seems unremarkable. She has been hospitalized once when she delivered healthy twin girls twenty years ago. She does recall having been told by her obstetrician that she had a heart murmur. She is married and works as a dental assistant in her husband's office. She smokes one pack of cigarettes daily and has done so for 30 years. She does not drink alcohol. On examination, she looks unwell. She is febrile with a temperature of 38.8 degrees Celsius. Her heart rate is 110 bpm with a BP of 100/65 mmHg. Head and neck examination reveals bilateral conjunctival petechiae. Her JVP is 4 cm above the sternal angle. Her chest is clear. Heart sounds reveal a grade 3/6 pan-systolic murmur best heard at the apex and an S3 with gallop. Her point of maximal impulse is enlarged and palpated in the anterior axillary line. She has mild bilateral pedal edema. Neurological examination, including fundoscopy, is completely normal as is the dermatologic exam. You decide to admit her to hospital, order blood work, a chest X-ray, and an echocardiogram.

General Objectives
Explain the concepts of afterload and preload (Frank-Starling relationship) and their effects on ventricular performance.
Describe the normal anatomy of the atrioventricular and semilunar valves and how they function.
Describe the pathophysiologic consequences and clinical presentations of the common types of valvular lesions.
Global Objectives
Upon completion of this problem, students should be able to describe how volume overload affects myocardial function.
Part 1
Medical Foundation 1
Cardiology
Week 4
Abnormal Heart Sounds and Murmurs
Weakness (not caused by Cerebrovascular Accident)
Concepts of Health and Its Determinants
Fever and Hyperthermia

Tutorial: Teresa J Part 2 MF1 Cardiovascular

Part 1, Medical Foundation 1, Cardiology, Week 4

You are called to see a patient in the ER who has presented with shortness of breath. You immediately recognize Teresa J, the 65-year-old female who was previously admitted for several weeks with acute lung injury earlier in the year. A quick review of her chart reminds you that she also has a history of poorly controlled diabetes and premature CAD with a prior MI at age 62. She looks distressed and is only able to talk in short phrases. She describes chest pain on the left side that gets worse when she coughs or moves. She has been getting weaker over the last 3 days. Her sputum is yellow, but she denies hemoptysis. She stopped taking all of her medications a week ago (furosemide, ASA, antihyperglycemics, metoprolol).

Global Objectives
Upon completion of this problem, students should be able to demonstrate integration of knowledge from across MF1.
Part 1
Medical Foundation 1
Cardiology
Week 4
Chest Pain
Cyanosis, Hypoxia
Dyspnea
Pleural Effusion

Active Large Group Session: Introduction to Immunology

Part 1, Medical Foundation 1, Introduction to Medicine, Week 2

Activity Objectives
Describe what is meant by inflammatory response.
Explain the key differences between innate and adaptive immune response.
Describe the different types of cells that are involved in the immune response (granulocytes, macrophages, lymphocytes, NK cells).
Define pathogen, phagocytosis, cytokine, MHC, antigen.
Explain the concept of antigen presentation.
Describe how the body defends against pathogens.
General Objectives
Describe the factors that determine airway calibre (upper and lower), including autonomic control and chemical mediators of inflammation.
Describe the response of the respiratory system to chronic inflammation.
Part 1
Medical Foundation 1
Introduction to Medicine
Week 2

Tutorial: Nabil Assad MF1 Respirology

Part 1, Medical Foundation 1, Introduction to Medicine, Week 2

Salim takes Nabil, his 7-year-old son, to see Dr. Lockwood, his family doctor, because both of them have a sore throat. Nabil’s younger brother had a sore throat and runny nose a week ago, but he improved quickly. Salim is concerned about Nabil because he seems to be taking longer to improve. Dr. Lockwood asks more details and learns that both Nabil and Salim are mostly having swallowing difficulties but feel otherwise quite well. Salim has a mild cough, but Nabil does not. There have been no rigors, just slight chills last night.

General Objectives
Describe the acute response of the respiratory system to inhaled material.
Identify and utilize effective strategies for retaining and retrieving new information, while minimizing time spent on strategies that are less effective.
Demonstrate the ability to reflect upon the strengths and weakness of their own communication skills.
Global Objectives
Identify and utilize effective strategies for retaining and retrieving new information, while minimizing time spent on strategies that are less effective
Demonstrate the ability to reflect upon the strengths and weakness of their own communication skills.
Recognize and describe viral versus bacterial infection of the upper respiratory tract.
Part 1
Medical Foundation 1
Introduction to Medicine
Week 2
Sore Throat and/or Rhinorrhea

Tutorial: Edwin McKenzie MF1 Respirology

Part 1, Medical Foundation 1, Introduction to Medicine, Week 2

Edwin is a 4-year-old boy enjoying a day at the Caledonia Fall Fair. He is walking around, enjoying the sights while eating a hot dog, when he suddenly begins to choke. Bystanders look on, horrified. An alert medical student, who happens to be taking a break from studying, is on the scene. She rushes over, comes up behind Edwin and administers an abdominal thrust. The piece of hot dog is expelled from Edwin, and he takes a big breath.He is fine, the medical student is relieved and congratulations are offered all around at this happy ending. In speaking with Edwin’s parents after the incident, the medical student notices a colorful circular pin on his mother’s jacket. The medical student inquires about the pin, and Edwin’s mother states the pin represents the Medicine Wheel, an important concept for their family’s health.

General Objectives
Describe the factors that determine airway calibre (upper and lower), including autonomic control and chemical mediators of inflammation.
Describe the acute response of the respiratory system to inhaled material.
Demonstrate the ability to participate in a group discussion, both by contributing to the discussion and by actively listening to the contributions of colleagues.
Explain the basic pathophysiology of the diseases which result in airway obstruction (upper and lower airway).
Explain a concept effectively in a group setting.
Evaluate how peers gave and received feedback.
Explain the effects of airflow obstruction on the respiratory tract, lung mechanics and gas exchange. Use this knowledge to explain the symptoms and signs with which the patient with lower or upper airway obstruction presents.
Global Objectives
Demonstrate the ability to participate in a group discussion, both by contributing to the discussion and by actively listening to the contributions of colleagues.
Explain a concept effectively in a group setting.
Give and receive simple feedback between colleagues appropriately.
Explain the pathophysiology and consequences of upper airway obstruction.
Identify aspects of the Medicine Wheel which are important to consider as part of Indigenous Health.
Part 1
Medical Foundation 1
Introduction to Medicine
Week 2
Indigenous Health
Dysphagia

Tutorial: Rana Osman MF1 Respirology

Part 1, Medical Foundation 1, Introduction to Medicine, Week 2

Rana Osman is a 2-year-old girl who has been previously well. She has had a barky, seal-like cough for 2 days but tonight has become acutely worse. In the emergency room, she is found to be sitting "bolt upright", with pronounced stridor on inspiration. Her inspiratory phase is prolonged. She has intercostal indrawing and suprasternal indrawing.

General Objectives
Describe the factors that determine airway calibre (upper and lower), including autonomic control and chemical mediators of inflammation.
Explain the normal mechanics of lung inflation and deflation, including the role of intrapleural pressure in inflation of the lung and the role of tissue elasticity and surface tension in elastic recoil of the lung.
Demonstrate the ability to participate in a group discussion, both by contributing to the discussion and by actively listening to the contributions of colleagues.
Explain the basic pathophysiology of the diseases which result in airway obstruction (upper and lower airway).
Explain a concept effectively in a group setting.
Explain the effects of airflow obstruction on the respiratory tract, lung mechanics and gas exchange. Use this knowledge to explain the symptoms and signs with which the patient with lower or upper airway obstruction presents.
Global Objectives
Demonstrate the ability to participate in a group discussion, both by contributing to the discussion and by actively listening to the contributions of colleagues.
Explain a concept effectively in a group setting.
Give and receive simple feedback between colleagues appropriately.
Explain the difference between extra-thoracic and intra-thoracic airway obstruction.
Part 1
Medical Foundation 1
Introduction to Medicine
Week 2
Pediatric Respiratory Distress

Tutorial: Ron Chen MF1 Respirology

Part 1, Medical Foundation 1, Introduction to Medicine, Week 3

Ron Chen is a 25 year old computer sciences post-graduate student who had been previously well. Three weeks ago he suffered a viral gastroenteritis from which he has recovered. Over the past week, he has noticed increasing weakness of his limbs, starting with his legs, and progressing to involve his arms. He reports he has experienced patchy areas of sensory loss, symmetrically. He has also noticed occasional clumsy speech and facial weakness.

General Objectives
Explain the normal mechanics of lung inflation and deflation, including the role of intrapleural pressure in inflation of the lung and the role of tissue elasticity and surface tension in elastic recoil of the lung.
Explain the pathophysiology of some of the common disease processes affecting the respiratory pump (upper airway, neuromusculature, lower airways and lung parenchyma).
Describe how the mechanics of breathing are disturbed in examples of obstructive and non-obstructive (“restrictive”) diseases.
Explain the assessment of respiratory pump failure using diagnostic tests.
Develop a mechanism-based approach to management of respiratory pump failure.
Global Objectives
Upon completion of this problem, students should be able to explain the role of the neuromusculature in respiratory pump function.
Part 1
Medical Foundation 1
Introduction to Medicine
Week 3
Dyspnea
Language and Speech Disorders
Weakness (not caused by Cerebrovascular Accident)

Tutorial: Celia and Maria MF2 Renal

Part 2, Medical Foundation 2, Renal, Week 1

Maria is a 33 year old single woman who is concerned about the health of her 2 year old daughter Celia. Since three months of age Celia has been treated with multiple course of antibiotics for episodes of fever and irritability. Maria wants the doctor to check a urine sample because she thinks it might be a "urine infection" since Celia's wet diapers have a bad smell

General Objectives
Explain the structure, function and physiology of the urinary tract, kidney, nephron and glomerulus
Describe the pathogenesis and clinical significance of infection involving the urinary tract.
Describe renal and bladder anatomy and visualize with an ultrasound.
Describe the pathogenesis and clinical significance of infection involving the urinary tract.
Global Objectives
Upon completion of this problem, students should be able to discuss features and causes of urinary tract infection and types and etiology of kidney stones.
Part 2
Medical Foundation 2
Renal
Week 1
Lower urinary tract symptoms
Dysuria, Urinary Frequency and Urgency, and/or Pyuria
Fever in the Immune Compromised Host / Recurrent Fever
Incontinence, Urine, Pediatric (Enuresis)
Fever and Hyperthermia

Tutorial: Matthew Clarke MF2 Renal

Part 2, Medical Foundation 2, Renal, Week 1

Matthew Clarke, a 4-year-old boy, developed periorbital edema for the first time three weeks ago, and despite being treated for allergies he showed increasing edema and weight gain. He now has ankle and leg edema, a distended abdomen, and can only sleep at night if propped up with three or four pillows.

General Objectives
Describe the determinants of intracellular fluid (ICF) and extracellular fluid (ECF) volume.
Describe the role of the urinalysis in detecting the presence of glomerular disease.
Explain the mechanisms of action by which diuretics, beta blockers, ACE inhibitors, ARBs, and calcium channel blockers reduce elevated blood pressure.
Understand the renal cortex, medulla, renal pyramids, renal papilla, renal columns.
Global Objectives
Upon completion of this problem, students should be able to explain fluid homeostasis in the human body and apply this to clinical problems, specifically how it is disrupted in nephrotic syndrome.
Part 2
Medical Foundation 2
Renal
Week 1
Abdominal Distension
Blood in Urine/Hematuria
Abnormal, Serum Lipids
Pleural Effusion
Proteinuria
Generalized Edema
Hyponatremia
Urticaria, Angioedema

Tutorial: Yong Mun Park MF2 Renal

Part 2, Medical Foundation 2, Renal, Week 3

Yong Mun Park is a 22 year old woman who has a 2 year history of recurrent urinary tract infections. These continue despite conservative measures and her family doctor elects to try her on a course of prophylactic antibiotics. She is allergic to sulpha medications, so she is prescribed cephalexin 250 mg daily. She is taking an oral contraceptive, but no other medications. Ten days after starting this antibiotic, she returns to her family doctor with a macular, red rash on her trunk and arms, general malaise, and nausea.

General Objectives
Describe and apply the role of the kidney in the metabolism and excretion of drugs.
Describe the role of the urinalysis in detecting the presence of glomerular disease.
Describe and the relationship between serum creatinine and GFR.
Explain the nephrotoxic potential of certain drugs.
Global Objectives
Upon completion of this problem, students should summarize the causes, presentations and renal manifestations of intrinsic causes of acute kidney injury particularly an allergic reaction.
Part 2
Medical Foundation 2
Renal
Week 3
Lower urinary tract symptoms
Skin and Integument Conditions
Proteinuria
Vomiting and/or Nausea
Acute Kidney Injury (Anuria or Oliguria)

Tutorial: Maxwell Greenfield MF2 Hematology

Part 2, Medical Foundation 2, Hematology, Week 1

Maxwell Greenfield is a 32 M was admitted under the general medicine service last night with gastroenteritis. It is your first day on the hematology rotation and you are called to provide a consult for new onset pancytopenia in Maxwell. Maxwell has a history of Crohn’s disease, diagnosed at the age of 28. He is currently on methotrexate 20 mg subcut weekly to control his disease, which he has been on for the last two years. He does not take any other medications at home. He has no other medical problems. Maxwell initially presented to hospital with nausea, vomiting, and diarrhea after eating some old chicken he found at the back of the fridge. He did not have any blood in his bowel movements or mucous. He has note noted any fever.

General Objectives
Describe the normal production and destruction of red blood cells
Describe the factors that control under and over production of red blood cells.
Describe the role of iron, folic acid and vitamin B12 in hematopoiesis.
Develop a conceptual approach to diagnosis of anemia and polycythemia.
Global Objectives
Upon completion of this problem, students should be able to describe hematopoiesis.
Part 2
Medical Foundation 2
Hematology
Week 1
Vomiting and/or Nausea
Acute Diarrhea
Anemia

Active Large Group Session: Introduction to Pathology

Part 2, Medical Foundation 2, Hematology, Week 2

General Objectives
Describe normal renal pathology.
Part 2
Medical Foundation 2
Hematology
Week 2

Tutorial: Charlotte Bouchard MF2 Hematology

Part 2, Medical Foundation 2, Hematology, Week 4

Charlotte Bouchard is a 31 year old female who has presented to the ER with new onset shortness of breath. She is previously healthy with no history of medical problems and is not on any medications. She tells you her chest pain and shortness of breath started roughly six weeks prior and have gotten worse to the point she can barely take a few steps without having to stop. She’s also lost about 15 lbs in this time and has noted night sweats such that she has had to change her pajamas during the night. On exam, her pulse is 105, BP 115/87, SpO2 97% on R/A, Temp 37.2. She is not visibly distressed. Respiratory exam reveals decreased air entry on the left and you are able to palpate lymph nodes along her bilateral cervical chains and supraclavicular regions. You also appreciate enlarged lymph nodes in her bilateral axillae and inguinal regions. Her spleen is palpable 5 cm below the costal margin. Chest x-ray performed in the ER reveals a left-sided pleural effusion and is suspicious for a mediastinal mass. You order a follow up CT and this confirms a 15.3 cm mediastinal mass as well as diffuse hilar and axillary adenopathy.

General Objectives
Describe the differentiation and development of white blood cells.
Describe the classification of the types of white blood cells.
Describe the roles of neutrophils, monocytes, and lymphocytes.
Describe the pathophysiology that leads to white cell malignancies.
Recognize the most common types of white cell malignancies.
Global Objectives
Upon completion of this problem, students will be able to describe the role of the lymphocyte in the immune system, develop an introductory approach to the manifestations, diagnosis, and complications of lymphoma, and will be able to describe a palliative approach to care.
Part 2
Medical Foundation 2
Hematology
Week 4
Abdominal masses and pelvic masses
Lymphadenopathy
Mediastinal Mass

Tutorial: Jesse Knox MF2 Hematology

Part 2, Medical Foundation 2, Hematology, Week 4

Mr. Knox is a 22-year-old male undergoing chemotherapy treatment for Acute Myeloid Leukemia. He was seen in clinic last week for chemotherapy, and he was relieved to see that his neutrophil count was back up above 1 (ANC 1000). He had no evidence of bleeding, and his platelet count was 110. He tolerated his intravenous chemotherapy and anti-emetics well, and went home to recover for the weekend. Eight days later, Jesse is feeling unwell and checks his temperature as he has been taught to do – it reads 38.5 deg C orally, so he presents to the ER as instructed. Apart from the fever, his only complaint is a sore mouth. He denies cough, shortness of breath, dysuria or change in bowel movements. Physical exam reveals a tired and pale-looking young man. His blood pressure is 105/60, heart rate 125 bpm, respiratory rate 18 and a temperature of 38.9 deg C. His tongue has a white coating and his gums look sore. His central line catheter site appears clean.

General Objectives
Describe the differentiation and development of white blood cells.
Recognize the most common types of white cell malignancies.
Explain how the immune system responds to infection.
Describe common oncologic emergencies.
Global Objectives
Upon completion of this problem, students will be able to describe the normal immune system response to infection as well as how chemotherapy can cause myelosuppression.
Part 2
Medical Foundation 2
Hematology
Week 4
Oral Conditions
Fever in the Immune Compromised Host / Recurrent Fever

Tutorial: Billy Elliot MF2 Hematology

Part 2, Medical Foundation 2, Hematology, Week 5

Billy Elliot, an 18 year old male music store employee was brought into your emergency department after being involved in a motor vehicle accident at about 2:00 a.m. The paramedics that brought him in stated that he was the driver of a vehicle involved in a three car accident. The rescue squad required the "jaws of life" to extricate him from the car. The airbags were deployed, but the car sustained significant damage and the steering wheel was noted to be inches from the front seat after Billy was extricated. The paramedics conveyed that the patient was alert and talking at the scene and an IV was started. However, en route to the hospital, they noted that his pulse rate began to increase and the patient was diaphoretic.

General Objectives
Describe the basic red blood cell surface antigens (ABO, Rh) and their importance in transfusion medicine.
Describe the response of the cardiovascular and respiratory systems to too many red blood cells and too few red blood cells.
Describe the response of the cardiovascular and respiratory systems to bleeding.
Global Objectives
Upon completion of this problem, students should be able to identify and describe mechanisms of compensation and eventual failure of cardiovascular responses to sudden volume loss. Additionally, students should be able to connect and describe the consequences to and responses of other organ systems (renal, hematologic) to acute volume loss and hemodynamic compromise
Part 2
Medical Foundation 2
Hematology
Week 5
Cyanosis, Hypoxia
Acid-Base Abnormalities
Trauma
Hypotension/Shock
Chest Injuries
Vascular Injury

Tutorial: Shalini Mehta MF3 Reproduction

Part 3, Medical Foundation 3, Reproduction and Pregnancy, Week 1

Shalini Mehta is a successful 35-year-old lawyer who married five years ago. Her partner Varun is a 56-year-old judge who left his former wife to be with Shalini. He has three grown children and one grandchild. Varun was never as keen on starting a new family as Shalini, but he loves her and "wants what she wants". For the first three years of their marriage, Shalini continued on the birth control pill, as she wanted to focus on establishing her career further. She states that she had been on the pill since she was 18. Two years ago she stopped the pill and had hopes that she would be trying for her second baby by now.

General Objectives
Compare and contrast the normal sexual response of the adult male and female.
Explain the mechanism of conception and the factors that influence it.
Explain the factors that influence fertility in both the males and females.
Describe the normal menstrual cycle.
Global Objectives
Upon completion of this problem, students should be able to define infertility, to discuss its underlying causes and to describe a basic diagnostic approach to its evaluation. The student should be able to describe the psychological and sexual impacts of infertility.
Part 3
Medical Foundation 3
Reproduction and Pregnancy
Week 1
Infertility
Dysmenorrhea

Tutorial: Mary Jane Morrison MF3 Reproduction

Part 3, Medical Foundation 3, Reproduction and Pregnancy, Week 2

Mary Jane, a healthy 22-year-old woman, is seen in a walk-in clinic for abnormal vaginal discharge. She is otherwise healthy and not taking any medications. Her immunizations are up to date, though she is unsure if she received the HPV vaccination as a teen. Mary Jane has been sexually active for 2 years. She has never had a Pap smear. She tells you that she has tried the birth control pill in the past but is not taking it because it “makes her sad”. She uses condoms instead. Three months ago, she had unprotected sex one time with her current partner. She confides in you that she thinks her current partner "sleeps around" on her and she’s here today because she wants to get “checked”. When taking a detailed sexual history, you discover that she has intermittently experienced pain during sexual intercourse and some post-coital bleeding. Mary Jane minimizes these symptoms and tells you that this is normal for her. On examination she looks well but is very nervous. Vitals signs are within normal limits. Head and neck, respiratory and cardiac examinations are all normal. Abdominal exam does not reveal any masses or areas of tenderness. Skin and joints are all normal. Genital examination does not reveal any lesions. Pelvic examination reveals some purulent discharge from the cervical os. Swabs are collected from the cervical os and result in bleeding. Bimanual examination does not elicit any cervical or adnexal tenderness. You discuss the role of cervical cancer screening and how it relates to HPV, a sexually transmitted infection. Mary Jane agrees to return in 2 weeks for a Pap smear.

Global Objectives
Upon completion of this problem, students will be able to discuss sexually transmitted infections.
Part 3
Medical Foundation 3
Reproduction and Pregnancy
Week 2
Vaginal Discharge / Vulvar Pruritis / STI
Amenorrhea, Oligomenorrhea

Tutorial: JoAnne Wright MF3 Reproduction

Part 3, Medical Foundation 3, Reproduction and Pregnancy, Week 3

JoAnne is a 28-year-old G4T1A2L1 Inuk from Baker Lake, Nunavut. Her last menstrual period was February 11. She has a regular, 28-day cycle and had a positive home urine test on March 14. She tells you that she is concerned because she had a DVT in her last pregnancy and was told that she has antiphospholipid antibody syndrome. She has been on warfarin since her son was born 2 years ago. She had 2 miscarriages at 8 and 10 weeks prior to her son being born. She is concerned about the effect of the medicine on her baby and also her risk of developing another clot.

General Objectives
Explain the normal physiological adaptations to pregnancy.
Describe the course of normal pregnancy and common causes of deviation from this course.
Define a teratogen.
Compare and contrast warfarin and low molecular weight heparin to illustrate the effects of a teratogen on the developing fetus.
Global Objectives
Upon completion of this problem, students should have explored teratogenicity in pregnancy using warfarin and low molecular weight heparin as examples.
Part 3
Medical Foundation 3
Reproduction and Pregnancy
Week 3
Indigenous Health
Early Pregnancy Loss / Spontaneous Abortion
Prenatal Care
Prevention of Venous Thrombosis
Concepts of Health and Its Determinants

Tutorial: Li Chin and Baby Albini MF3 Reproduction

Part 3, Medical Foundation 3, Reproduction and Pregnancy, Week 4

Li Chin is a 19-year-old woman from Hong Kong who has been in Canada for one year studying Computer Science at McMaster University. She is a known carrier of Hepatitis B, but is otherwise healthy and on no medication. You are a family physician working at Student Health Services at the university. Li came to see you today for a routine prenatal appointment at 28 weeks gestational age. You inquire as to Li's plans for feeding her baby after birth. She is uncertain and has not yet considered this. When you recommend that she breastfeed her baby, she asks why. She doesn’t know anyone who has breastfed. She is uncertain as to whether or not she would be able to do it.

General Objectives
Describe the anatomy of the female breast as related to lactation.
Explain the physiology of normal lactation and the benefits of breastfeeding.
Global Objectives
Upon completion of this problem, students will be able to describe the process of lactation and discuss the advantages and barriers to breastfeeding. Students will also be able to explain how disruptions in the normal flora can lead to Candidal infection.
Part 3
Medical Foundation 3
Reproduction and Pregnancy
Week 4
Prenatal Care
Newborn Assessment

Tutorial: Nick DeMarco MF3 Gastroenterology and Nutrition

Part 3, Medical Foundation 3, Gastroenterology and Nutrition, Week 1

Nick DeMarco is a 51 year old physical education teacher at a local elementary school. He has noticed increasing fatigue with exertion and complains about feeling exhausted at the end of the school day. He explains that he has been experiencing epigastric discomfort after eating and he has tried taking Advil for pain relief. He states the pain and regurgitation wakes him up at night. He reports that he is usually able to get back to sleep after taking antacids and a glass of milk.

General Objectives
Explain how the gastrointestinal mucosa functions as a barrier to the outside world of healthy microbes and pathogens.
Describe the role of the microbiome in normal digestive physiology and pathology.
Describe factors that play a significant role in maintaining gastrointestinal mucosa integrity.
Explain how disruption in any of these factors are significant in the development of many diseases including peptic ulcer disease, celiac disease, infectious and inflammatory bowel diseases in addition to potential roles in diabetes or other autoimmune diseases.
Global Objectives
Upon completion of this problem, students will demonstrate an understanding of the physiology and pathophysiology of gastric acid secretion. The factors that support and disrupt gastroduodenal mucosal integrity should be identified and explained.
Part 3
Medical Foundation 3
Gastroenterology and Nutrition
Week 1
Fatigue
Vomiting and/or Nausea
Weight Loss / Eating Disorders / Anorexia
Chronic Abdominal Pain

Tutorial: James Cork MF3 Gastroenterology and Nutrition

Part 3, Medical Foundation 3, Gastroenterology and Nutrition, Week 2

Dr. James Cork, a 26 year old dentist, has been unwell for over 1 year. During this time he reports he has had diarrhea characterized by four to six loose, bulky stools per day without blood, mucus, or pus. He has been up at least once each night to move his bowels. James has lost 7 kg despite a very good appetite. He has not travelled outside of southern Ontario or been camping. His partner of 7 years, Richard, is in good health and has not suffered any of these symptoms, nor has James been in contact with anyone else with similar symptoms. His family physician found that his hemoglobin is low.

General Objectives
Describe the enteral digestion, absorption and metabolism of macronutrients and micronutrients.
Describe the steps of digestion and absorption and roles of the key organs of the alimentary tract in these processes.
Describe normal gastrointestinal histology.
Describe and understand the small bowel, its length and divisions: duodenum, parts (first, second, third and fourth), duodenal cap or bulb, openings into the duodenum, duodenojejunal junction, ligament of Treitz, blood and nerve supply and its lymph drainage.
Global Objectives
Upon completion of this problem, students will be able to describe the physiology of the small intestine and discuss the pathophysiology of malabsorption.
Part 3
Medical Foundation 3
Gastroenterology and Nutrition
Week 2
Genetic Concerns
Bleeding, Bruising
Chronic Diarrhea
Weight Loss / Eating Disorders / Anorexia

Tutorial: Ted Mitchell MF3 Gastroenterology and Nutrition

Part 3, Medical Foundation 3, Gastroenterology and Nutrition, Week 2

Ted Mitchell is a 38 year old male who is homeless. He has been on and off the streets for the last 15 years. As a teenager, he started hanging out with "the wrong crowd" and his father, Dr. Ted Mitchell Sr. told him he could not return home till "you have cleaned up your act". Ted continues to abuse drugs, and any money he can get, has gone toward purchasing alcohol, his drug of choice.

General Objectives
Describe the structure and function of the hepatobiliary system.
Describe an approach to assessment, investigation and management of patients with disorders of the hepatobiliary system.
Understand the portal system, sites of porto systemic anastomosis, portal hypertension (pre, intra and post hepatic).
Describe normal gastrointestinal histology.
Identify the liver, its lobes, ligaments. Its blood, nerve supply and lymph drainage.
Global Objectives
Upon completion of this case, students will be able to describe the normal structure and function of the liver, as well as changes to structure and function present in pathological states.
Part 3
Medical Foundation 3
Gastroenterology and Nutrition
Week 2
Abdominal Distension
Jaundice
Abnormal Liver Function Tests
Substance Use or Addictive Disorders
Vomiting and/or Nausea

Tutorial: Mike Bayuk MF3 Gastroenterology and Nutrition

Part 3, Medical Foundation 3, Gastroenterology and Nutrition, Week 2

Mike Bayuk, a 55 year old businessman, presents to the ER in Hagersville with severe abdominal pain. He indicates that the pain is located in the epigastric area and radiates into his back. He finds the pain is relieved when he sits up with his trunk flexed and his knees bent. He rates the pain as "11 out of 10".

General Objectives
Identify the pancreas its divisions, ducts (major and minor duct), blood, nerve supply and lymph drainage.
Global Objectives
Upon completion of this problem, students should be able to describe the approach to a patient presenting with acute abdominal pain, describe the basic anatomy and physiology of the pancreas and examine the pathophysiology of acute and chronic pancreatitis.
Part 3
Medical Foundation 3
Gastroenterology and Nutrition
Week 2
Acute Abdominal Pain

Active Large Group Session: Autoimmunity

Part 3, Medical Foundation 3, Gastroenterology and Nutrition, Week 2

Activity Objectives
Discuss the concept of autoimmunity, the role of the thymus in its development and its role in various disease states.
List the cells that mediate autoimmune conditions.
Describe the roles of the innate and adaptive immune systems as well as the mucosal immune system in the pathogenesis of Celiac disease.
Explain the roles of B- and T-cells in the development of Hashimoto’s thyroiditis and the different theories regarding mechanisms of thyroid injury in this context.
List the autoantigens associated with T1DM.
Outline the contribution of the cellular immune system in the pathogenesis of T1DM.
List autoimmune diseases commonly associated with T1DM.
Part 3
Medical Foundation 3
Gastroenterology and Nutrition
Week 2
Diabetes Mellitus

Tutorial: John Franks MF3 Gastroenterology and Nutrition

Part 3, Medical Foundation 3, Gastroenterology and Nutrition, Week 3

John Franks is a 66-year-old male with a complicated course of Crohn’s disease over 30 years, requiring multiple surgical resections of his small bowel due to inflammation and obstruction. He has been treated with several immunosuppressive and biological treatments for his IBD, but has had a loss of response to these medications despite some temporary improvement in his disease activity. Despite currently being on ustekinumab (Stelara), John has had evidence of active disease and is currently on a tapering course of prednisone for a recent flare of his IBD. He was recently admitted to hospital with another partial small bowel obstruction and he is worried that he may need further surgery. "They’ve removed so much of my small intestine already that I am worried that I’m going to get short bowel syndrome." You discuss optimizing his dosages of his treatments in an attempt to induce remission of his disease, and to avoid the need for further surgery. He asks: "If I do have short bowel syndrome, what kind of special diet will I need to go on to maximize my nutrition?"

General Objectives
Describe the role of foods and nutrients in the prevention and management of chronic disease, with a focus on type 2 diabetes, atherosclerotic cardiovascular disease, and some cancers.
Describe the role of diet in the pathophysiology of disease and the therapeutic benefits of specific nutrients and dietary practices.
Global Objectives
Upon completion of this problem, students should be able to describe the pathophysiology and consequences of chronic inflammation in the bowel, including the pathogenesis of short bowel syndrome in patients with Crohn’s disease.
Part 3
Medical Foundation 3
Gastroenterology and Nutrition
Week 3
Chronic Diarrhea

Tutorial: Philip Cheung MF3 Gastroenterology and Nutrition

Part 3, Medical Foundation 3, Gastroenterology and Nutrition, Week 3

Mr. Cheung presents to the emergency department with a 2 day history of worsening pain in the right upper quadrant of his abdomen. He had been in the ER last year with pain in his right flank, but while that pain was colicky in nature, he currently describes a more constant pain. The right flank pain a year ago was accompanied by hematuria and he ended up passing a kidney stone. Currently, he has felt nauseated but has not vomited and he has been anorexic for over 24 hours. He finally came to ER after developing some fevers and chills.

General Objectives
Describe the structure and function of the hepatobiliary system.
Describe an approach to assessment, investigation and management of patients with disorders of the hepatobiliary system.
Identify the gall bladder, its division and function, blood, nerve supply and lymph drainage .
Identify and understand the biliary tree (right and left hepatic duct, common hepatic duct, cystic duct, common bile duct), major and minor duodenal papilla, ampulla of Vater and sphincter of Oddi.
Global Objectives
Upon completion of this problem, students will be able to describe the anatomy and physiology of the biliary system and outline the pathophysiology of stone formation in various organs.
Part 3
Medical Foundation 3
Gastroenterology and Nutrition
Week 3
Vomiting and/or Nausea
Chronic Abdominal Pain
Fever and Hyperthermia

Tutorial: Vivian Patel MF3 Gastroenterology and Nutrition

Part 3, Medical Foundation 3, Gastroenterology and Nutrition, Week 4

Vivian Patel is a 35-year-old computer programmer who presents to the ER with a 10- hour history of profuse vomiting, watery non-bloody diarrhea and abdominal cramps. She first tried to fight this illness on her own by drinking water, however her symptoms were persistent and her husband brought her to the emergency room. She was first seen by the triage nurse, who noted that she was febrile with a temperature of 38.6 C. Given her presentation, the nurse decided that she should be isolated with "enteric precautions” and she was subsequently seen by the ER physician. Vivian is an otherwise healthy woman with no known medical problems and only takes a multivitamin daily. The day prior to her presentation with these symptoms, she had attended her 5-year-old niece's birthday party. She cannot recall any sick contacts, although is unsure if anyone else from the party has developed similar symptoms. Additionally, she had recently returned from a trip to India 5 days ago. She went on a business trip for a week and stayed to travel the country for another 3 thereafter. She did not receive any pre-travel advice or prophylaxis.

General Objectives
Explain how the gastrointestinal mucosa functions as a barrier to the outside world of healthy microbes and pathogens.
Describe the role of the microbiome in normal digestive physiology and pathology.
Describe factors that play a significant role in maintaining gastrointestinal mucosa integrity.
Describe normal gastrointestinal histology.
Explain how disruption in any of these factors are significant in the development of many diseases including peptic ulcer disease, celiac disease, infectious and inflammatory bowel diseases in addition to potential roles in diabetes or other autoimmune diseases.
Identify and describe the large bowel , its length and divisions: cecum, appendix, ascending and descending colon, transverse and sigmoid colon, rectum and anal canal. Understand gross differences between large and small bowel. Blood, nerve supply and lymph drainage of the large bowel with a focus on porto systemic anastomosis at the anal canal.
Global Objectives
Upon completion of this problem, students should be able to outline the anatomic structure and function of the colon (large intestine). Students will also be able to discuss the pathogenesis of gastroenteritis and the public health approaches to its control.
Part 3
Medical Foundation 3
Gastroenterology and Nutrition
Week 4
Vomiting and/or Nausea
Acute Abdominal Pain
Acute Diarrhea
Chronic Abdominal Pain
Fever and Hyperthermia
Outbreak Management

Tutorial: Stephen Golding MF3 Endocrinology

Part 3, Medical Foundation 3, Endocrinology, Week 1

Stephen Golding, a 22 year old man presents to the emergency department with nausea, vomiting, abdominal pain and a 3-day history of polyuria, polydipsia, and weight loss. He states that he has "junvenille insulin-dependent" diabetes but stopped taking his insulin 5-days ago.

General Objectives
Describe the structure and function of the endocrine pancreas, the role of glucose as a fuel, and the physiology of plasma glucose regulation, insulin synthesis and release.
Describe the role of insulin in energy metabolism.
Explain the classification, epidemiology, diagnosis and pathophysiology of diabetes mellitus.
Explain the pathogenesis of diabetic ketoacidosis (DKA) and its management.
List and describe treatment options for diabetes mellitus.
Describe the interplay between nutrition and endocrine disease.
Global Objectives
Upon completion of this problem, students will be able to describe the role of insulin in lipid, carbohydrate and protein metabolism in normal homeostasis and and appreciate the consequences of the pathophysiological condition of absolute insulin deficiency.
Part 3
Medical Foundation 3
Endocrinology
Week 1
Acid-Base Abnormalities
Vomiting and/or Nausea
Acute Abdominal Pain
Diabetes Mellitus
Polyuria and/or Polydipsia
Weight Loss / Eating Disorders / Anorexia

Tutorial: Adam Pajek MF3 Endocrinology

Part 3, Medical Foundation 3, Endocrinology, Week 2

A 40-year old man, Adam Pajek, was seen in a walk-in clinic complaining of palpitations, heat intolerance (felt hot when others were comfortable or cold), sweating, anxiety, weight loss, fatigue, and sleeplessness for two months. He reports that his sister has a hypothyroid problem for which she takes Eltroxin pills.

General Objectives
Recognize the pituitary as the central control gland of the body.
Outline the synthesis and secretion of thyroid hormones, the types of thyroid hormone and the feedback loops governing interactions between the pituitary gland and the thyroid gland.
Explain the physiological function of thyroid hormone, including its effects on basal metabolic rate.
Explain the laboratory abnormalities and clinical manifestations seen in thyroid dysfunction.
Describe the treatment of thyroid disease.
Global Objectives
Upon completion of this problem, students will describe the role of thyroid hormones in energy metabolism.
Part 3
Medical Foundation 3
Endocrinology
Week 2
Fatigue
Neck Mass, Goiter, Thyroid Disease
Palpitations
Anxiety
Sleep-Wake Disorders
Weight Loss / Eating Disorders / Anorexia

Tutorial: Pia Meta MF3 Endocrinology

Part 3, Medical Foundation 3, Endocrinology, Week 2

Pia Meta is a 21-year-old female university student with paroxysmal attacks of palpitations, dizziness, blurring of vision and headache over the past 6 months. Each attack persists for a few minutes to half an hour. They occur irregularly with essentially no warning. She reports that during one of her attacks, she went to the emergency department and was found to have a blood pressure of 210/140 mmHg. She was told that she was having a panic attack. She was previously well and has no significant family history. Pia occasionally consumes alcohol on weekends only. She denies the use of any medications or recreational drugs, particularly methamphetamines or other sympathomimetics. She has one cup of coffee per day unless she is studying for exams, in which case she drinks 2-3 cups per day at most. She lives with roommates with whom she attends McMaster University. She has been performing well at school and has an active social life. On examination in the clinic, she has no abnormal physical findings.

General Objectives
Outline the structure and function of the adrenal gland.
Describe the control of each of the hormones produced by the adrenal gland.
Summarize the clinical manifestations of excess or inadequate production of adrenal hormones, especially with respect to glucocorticoids and catecholamines.
Global Objectives
Upon completion of this problem, students will be able to describe the anatomy and physiology of the adrenal gland. Students will be able to summarize the physiological role of catecholamines and the consequences of catecholamine excess.
Part 3
Medical Foundation 3
Endocrinology
Week 2
Dizziness, Vertigo
Headache
Palpitations

Tutorial: Emily Bradstone MF3 Endocrinology

Part 3, Medical Foundation 3, Endocrinology, Week 2

A 55 year old female, Emily Bradstone, is seen by a hematologist for easy bruising. No hematological problem was found. An internist also saw the patient. There has been a one-year history of easy bruising, weight gain, worsening of diabetes, difficulty climbing stairs and edema of the ankles

General Objectives
Outline the structure and function of the adrenal gland.
Recognize the pituitary as the central control gland of the body.
Examine the anatomic and functional relationship between the pituitary and hypothalamus.
Describe the control of each of the hormones produced by the adrenal gland.
Identify the diurnal pattern of adrenal cortex secretion, as well as the effect of stress on adrenal function.
Describe Cushing Syndrome, its causes and its manifestations.
Global Objectives
Upon completion of this problem, students will be able to describe the regulation and function of the hypothalamic-pituitary-adrenal axis.
Part 3
Medical Foundation 3
Endocrinology
Week 2
Bleeding, Bruising
Weight Gain, Obesity

Tutorial: Joan Spaulding MF4 MSK

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 3

Joan Spaulding is a 32 year old lady who arrives at your clinic with a history of joint pains in the hand. The pain in her hands was predated by a viral flu that manifested itself as generalized arthralgias and fatigue. The pain has been ongoing for 10 weeks and transformed itself from generalized arthralgias to symptoms in the hands and feet associated with morning stiffness that lasts approximately 1 hour.

General Objectives
Describe how the immune system is closely tied in with many disease entities affecting the musculoskeletal system. Central concepts include inflammation, the adaptive and innate immunities and Th1 and Th2 factors.
Describe the scope and multi-system nature of many autoimmune musculoskeletal diseases.
Describe the clinical difference and approach to monoarthritis and polyarthritis.
Discuss rheumatic disorders, including vascultis and myopathies, that present with overlapping neurological symptoms.
Global Objectives
Upon completion of this problem, students will be able to describe the diagnosis and management of rheumatoid arthritis and will have an approach to extra-articular manifestations.
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 3
Polyarthralgia (Pain in More Than Four Joints)
Non-Articular Musculoskeletal Pain

Tutorial: Jane Young MF4 MSK

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 3

Jane Young is a 3 1/2 year-old girl, brought to the Pediatric Medicine Clinic by her mother. For the past 10 days, her right knee has been swollen and stiff. There was no preceding trauma. She seems to have most symptoms in the morning, getting better when she is up and about playing. She seems to have less energy since the swelling was first noted. Her mother has been giving her children's Tylenol but has not noticed any improvement in her symptoms. Her mother thinks her ankles are also "puffy" at times. On examination, Jane appears well, afebrile and is on the 50th percentile for height and weight. No fever or skin rashes. Cardiovascular, respiratory and abdominal examinations unremarkable. Right knee is swollen, warm and effused and Jane stands with this knee slightly flexed. There are mild effusions of both ankles which are also slightly swollen. The pediatrician decides to order a few investigations. Baseline CBC, renal and liver function is unremarkable. ESR moderately elevated at 30. Rheumatoid Factor is negative, but Antinuclear Antibody (ANA) is positive at 1:160.

General Objectives
Describe the scope and multi-system nature of many autoimmune musculoskeletal diseases.
Global Objectives
Upon completion of this problem, students will be able to explain key concepts in Juvenile Idiopathic Arthritis (JIA).
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 3
Limp in Children
Fatigue
Generalized Edema
Oligoarthralgia (Pain in One to Four Joints)

Active Large Group Session: Inflammatory Arthritis

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 3

Activity Objectives
Describe the inflammatory cascade.
Describe how alterations in the inflammatory cascade can lead to pathogenesis of certain diseases.
Compare and contrast clinical presentations of rheumatoid arthritis, seronegative spondyloarthropathy, and connective tissue diseases.
Explain how pharmacological therapy functions to suppress inflammation at various parts of the immune response cascade.
Explain how inflammatory conditions have a significant impact on the quality of life of patients affected.
General Objectives
Summarize the basics in immunity, inflammation and the concept of autoimmunity.
Identify that there are many triggers to inflammation and factors that mediate it.
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 3
White Blood Cells, Abnormalities of
Oligoarthralgia (Pain in One to Four Joints)
Localized Edema

Tutorial: Joseph Collins MF4 MSK

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 3

Joseph is a 34-year-old man who arrives at the emergency room having returned from a vacation to Cuba 3 weeks ago. He had profuse diarrhea for about 5 days while he was in Cuba. The diarrhea settled by the time he returned to Canada. His primary concern now is swelling and pain in his right knee, left ankle, and left elbow. He is worried that infection from the diarrhea has somehow gotten into his joints. He asked whether he should have received antibiotics while in Cuba, and whether he needs any right now.

Global Objectives
Upon completion of this problem, students will be familiar with reactive arthritis and recognize that environmental and genetic factors have a significant role in the pathophysiology of rheumatic diseases.
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 3
Acute Diarrhea
Oligoarthralgia (Pain in One to Four Joints)

Tutorial: Cindy Edsworth MF4 MSK

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 3

Mrs. Cindy Edsworth is a 30 year old African Canadian lady who describes the onset of joint pains which have been on going for 3 months. She describes that the small joints of her hands are constantly aching and over the past 4 weeks she describes having swelling in the PIP and DIP joints of both hands. Over the past week she points out that she is having significant swelling affecting the feet that reaches the ankles. With the onset of the joint pains she developed alopecia and a scarring type rash over the scalp. She has been quite fatigued. She finds she is exhausted when she awakens in the morning and by 6:00 pm she has to go to bed because of persistent fatigue. Cindy also finds that she has become quite irritable. Her temper is easily disturbed and she is also becoming quite argumentative with her husband. Her husband is disturbed by her recent change in mood.

Global Objectives
Upon completion of this problem, students will be able to describe systemic lupus erythematosus.
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 3
Black Health
Blood in Urine/Hematuria
Fatigue
Skin and Integument Conditions
Psychosis
Chronic Kidney Injury
Polyarthralgia (Pain in More Than Four Joints)

Tutorial: Theodore McIntyre MF4 MSK

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 4

Mr. McIntyre, a 69 year old man, has developed a new onset right-sided headache for the last 5 days. He has some pain when he chews his food and has been feeling increasingly fatigued. He has had stiffness in his shoulders and his hips so much so that it takes him at least an hour to get up and move around first thing in the morning. He has started to develop some double vision. He has tenderness when he combs his hair on the right side of his temple. Physical exam reveals a BP of 120/70 (right arm) and 126/68 (left arm), HR 75/min, temp 37. He has tenderness along his R temporal region and the R temporal artery feels thickened.

Global Objectives
Upon completion of this case, students will be able to describe Giant Cell Arteritis as one type of vasculitis.
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 4
Diplopia
Fatigue
Headache
Oral Conditions
Acute Visual Disturbance/Loss
Oligoarthralgia (Pain in One to Four Joints)

Tutorial: Giuseppe Carnivale MF4 MSK

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 4

Giuseppe Carnivale is a 42 year old construction worker who presents with the complaint of gradually increasing weakness in his legs. He has noted difficulty climbing stairs. He feels the strength in his arms is normal, except when working over his head. He admits to mild aching in his muscles, but has no muscle pain or tenderness. The weakness has been insidious. A rash has been present on his face and upper chest for several months.

Global Objectives
Upon completion of this problem, the students will have an overall approach to weakness, and will be able to describe inflammatory muscle disease.
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 4
Skin and Integument Conditions
Weakness (not caused by Cerebrovascular Accident)
Polyarthralgia (Pain in More Than Four Joints)

Tutorial: Fred Newman MF4 MSK

Part 4, Medical Foundation 4, Musculoskeletal Medicine, Week 4

Fred Newman, a 32-year-old man, complains of severe low back pain of gradual onset over the past few years. The pain is much worse in the morning and gradually decreases during the day. He denies fever or weight loss but does feel fatigued.

General Objectives
Differentiate between inflammatory and mechanical back pain.
Global Objectives
Upon completion of this problem, students will be able to explain the difference between inflammatory and mechanical back pain, and will have explored ankylosing spondylitis as the prototypical inflammatory spine disease.
Part 4
Medical Foundation 4
Musculoskeletal Medicine
Week 4
Back Pain and Related Symptoms (e.g., Sciatica)
Fatigue
Polyarthralgia (Pain in More Than Four Joints)

Tutorial: Mandy Wallsmith (Part 2) MF4 Neurology

Part 4, Medical Foundation 4, Neuroscience, Week 1

Six months after her previous presentation of transverse myelitis, from which she completely recovered, Mandy Wallsmith returns with complaints of bilateral visual loss (worse on the right). The problem started two days ago with pain in and behind her right eye, worse when she would look to the left or right. Yesterday, she began to notice that she wasn't seeing well out of her right eye. Today her vision seems worse, although the pain is a little better. On examination, her visual acuity is found to be 20/80 in the left eye (OS) and 20/400 in the right eye (OD). Visual field appears to be normal in the left eye, but she can only detect hand motion (not finger counting) in all quadrants with the right eye. She finds that colours look less vivid with her right eye - especially red, which looks "kind of gray".

General Objectives
Recognize the anatomy and physiology of the eye; cones, rods, eye ball, optic nerve.
Describe the anatomy of optic nerve and optic chiasm.
Explain the basic pathophysiology and common clinical presentations of multiple sclerosis.
Global Objectives
Upon completion of this problem, students should be able to discuss the anatomy and physiology of the eye and optic nerves.
Part 4
Medical Foundation 4
Neuroscience
Week 1
Acute Visual Disturbance/Loss

Tutorial: Mandy Wallsmith (Part 1) MF4 Neurology

Part 4, Medical Foundation 4, Neuroscience, Week 1

Mandy Wallsmith is a 19-year-old young lady who has been brought to the Emergency Department because of problems walking. Approximately one week ago, she noticed some numbness in her left leg. She thought she had slept on it the wrong way initially, but then the numbness persisted. The next day she fell while skating and landed on her backside. Over the next few days, she reports feeling significant pain in her lower back and progressive “heaviness” in her left leg. She began having difficulty lifting her left leg. She also noticed that her right leg seemed to feel cold when she showered. After speaking to her parents about her symptoms, she was brought to a walk-in clinic where an x-ray of the spine was ordered. This reported no fractures, and Mandy was advised to follow-up with her family doctor if her symptoms did not improve in the next few days. When she started to have episodes of urinary incontinence, her parents became very concerned, and decided to bring her to the Emergency Department.

General Objectives
Explain the organization of the two major sensory systems of the spinal cord.
Differentiate peripheral versus central loss of sensation.
Contrast upper versus lower motor neuron dysfunction.
Global Objectives
Upon completion of this problem, students should be able to describe the anatomy and physiology of the spine.
Part 4
Medical Foundation 4
Neuroscience
Week 1
Back Pain and Related Symptoms (e.g., Sciatica)
Numbness / Tingling / Altered Sensation
Weakness (not caused by Cerebrovascular Accident)
Incontinence, Urine, Adult

Tutorial: David Beatty MF4 Neurology

Part 4, Medical Foundation 4, Neuroscience, Week 2

David Beatty is a 5 year old boy brought to his family doctor by his mother. She is concerned about his clumsiness. He had always been a little 'slow' with his gross-motor milestones. His mother recalled that he did not start walking until he was 20 months old. As he has gotten older, he has seemed less able to keep up with other children his age. As an example she explains that she sees other kindergarten children at the school playground who all seem to be able to run, climb and hop without difficulty. But not David. He is slow, cannot climb well, and falls very often. He also tires out quickly. She worries that maybe he has a problem with the bones in his legs, or maybe a problem with his hips. On examination, David is 111 cm tall (50th percentile), weighs 21 kg (75th percentile), and has a head circumference of 52 cm (75th percentile). He is a happy boy and is eager to tell stories about his teacher and classmates. When standing he has a prominent lordotic curve to his back. He has difficulty climbing up on the examination table, but insists on doing it himself. His heart, lungs and abdomen appear normal. His joints have full range of motion and he does not appear to have any joint or bone pain. His muscle bulk appears to be good - in fact he has large, muscular-looking calves. His deep tendon reflexes are normal (grade 2 out of 4).

General Objectives
Discuss the microscopic structure of muscle and the process of muscle contraction/relaxation.
Recognize the major milestones for gross motor development.
Differentiate inflammatory myopathies, metabolic myopathies, congenital structural myopathies, and dystrophies.
Develop an overall approach to weakness, leading into the neuroscience subunit.
Global Objectives
Upon completion of this problem, students should be able to describe normal muscle function.
Part 4
Medical Foundation 4
Neuroscience
Week 2
Falls
Fatigue
Ataxia (Gait)

Tutorial: Ivan Nettar MF4 Neurology

Part 4, Medical Foundation 4, Neuroscience, Week 2

Ivan is a 68 year old man who has enjoyed excellent health in the past. His only medication is hydrochlorothiazide for mild hypertension. For the past few weeks he noticed that by the end of the day he had difficulty focusing his eyes and keeping them open. He decided to see his family physician when the other day his vision became double. On the day of the visit, Ivan was feeling even worse. His double vision was present shortly after lunch and he felt generally weak. On observation, it was clear that Ivan had a right-sided ptosis. He kept closing one eye and then the other, complaining that otherwise his vision was double. His voice seemed mildly hoarse. Blood pressure was normal at 135/80. General physical examination of the heart, lungs, and abdomen was normal. Neurological examination showed that the pupils were equal and reactive. A prominent ptosis was present on the right. The extra ocular movements were abnormal with dysconjugate gaze present intermittently and not consistently on lateral, upward, and downward gaze. The other cranial nerves were normal. Tone was normal in the limbs. He had some difficulty holding up his arms in the air for more than a couple of minutes. He had some difficulty doing more that 5 deep knee bends. Sensation was normal and the reflexes were all present and symmetric. The plantar responses were down going. You ask Ivan to close his eyes and rest them for a few minutes while you make some notes. You ask him then to open his eyes and temporarily the double vision is much better and the ptosis is almost gone! A referral is made to the neurologist on call. She asks that you send Ivan to the emergency room so that she can perform a tensilon test to confirm the diagnosis.

General Objectives
Identify the anatomy and describe the physiology of the neuromuscular junction.
Global Objectives
Upon completion of this problem, students should be able to describe the normal function of the neuromuscular junction.
Part 4
Medical Foundation 4
Neuroscience
Week 2
Diplopia
Language and Speech Disorders
Weakness (not caused by Cerebrovascular Accident)

Tutorial: Ron Chen (Part 2) MF4 Neurology

Part 4, Medical Foundation 4, Neuroscience, Week 3

Remember back in MF1... Ron Chen is a 25 year old computer sciences graduate student who had been previously well. Three weeks ago he suffered a viral gastroenteritis from which he has recovered. Over the past week, he has noticed increasing weakness of his limbs, starting with his legs, and progressing to involve his arms. He reports he has experienced patchy areas of sensory loss, symmetrically (glove and stocking distribution). He has also noticed occasional clumsy speech and facial weakness. He is admitted to the hospital (medical ward) with a diagnosis of Guillain Barré syndrome. You see him in followup 12 months later. After spending 3 weeks in hospital, 4 weeks in a rehabilitation center and then having physiotherapy for the rest of the year, Ron is almost completely back to normal. He still reports some weakness with extension of his toes on the right, but this does not impair his functioning. During his visit, he asks if he will ever get the strength back in his toes, and whether this could happen again

General Objectives
Discuss the following electrophysiological concepts surrounding excitable cells: 1) resting potentials, 2) post-synaptic potentials, 3) action potential generation and propagation in unmyelinated and myelinated neurons.
Explain the clinical presentation and pathophysiology of length dependant neuropathies.
Global Objectives
Upon completion of this problem, students should be able to describe the fundamentals of nerve conduction in health and disease.
Part 4
Medical Foundation 4
Neuroscience
Week 3
Weakness (not caused by Cerebrovascular Accident)

Tutorial: Arielle D

Part 5, Integration Foundation

Arielle is a 41 yr old female presenting to her family doctors office with concerns of irregular menstrual cycles and painful intercourse. Arielle states she has noticed increased episodes of spotting in between her menstrual cycles over the past 8 months. Arielle has also noticed increased vaginal discharge and abdominal cramping at times with associated swelling of her legs. Arielle thought her lower leg symptoms were a result of her long work hours and standing for long periods of time. Arielle immigrated to Canada from the United States 15 years ago. She works as a daycare attendant and a waitress on the weekends to support her parents who reside with her and her partner. Arielle did not have regular access to healthcare as a teenager while living in Florida with her parents who immigrated to the US from Mexico shortly after Arielle was born. Arielle did not receive any vaccinations as a child or as a teenager. Arielle was sexually active at the age of 14 with multiple partners before her husband. She has been in a monogamous relationship for the past 6 years. Arielle reports she has given birth to 3 children which she gave up for adoption and underwent 2 pregnancy terminations prior to meeting her husband. Her husband does not know about any of the previous pregnancies or procedures she underwent prior to meeting him.

Global Objectives
Upon completion of this problem, students will be able to review risk factors for cervical cancer and the role of vaccines in decreasing these risks and describe different pathological results for cervical cancer screen and their associated treatments. Students will also examine barriers to successful cervical screening programs and implementation amongst marginalized populations.
Part 5
Integration Foundation
Vaginal Discharge / Vulvar Pruritis / STI

Tutorial: Yaser Kallas IF Host Defence and Neoplasia

Part 5, Integration Foundation, Host Defense and Neoplasia, Week 1

Yaser is a 36-year-old man who is brought to the emergency room by his wife after feeling quite unwell for the past 2 days with shaking chills and fever, along with some upset stomach. He is extremely weak and unable to provide significant details and his wife does not speak English. In reviewing his chart from a previous visit for a sprained ankle you are able to elicit that he’s a refugee from Syria who came to Canada 18 months ago and has two children. He was not previously taking any regular medications and he does not seem to have a significant past medical history other than a splenectomy secondary to a trauma 8 years ago. On assessment at triage he is found to have a temperature of 39.2 Celsius, a blood pressure of 86/60 and a heart rate of 125 bpm. His oxygen saturation is 85% on room air and he is tachypneic with a respiratory rate of 34. He is very drowsy, but rousable, however unable to engage in significant conversation. He appears diaphoretic and his extremities are warm to touch.

General Objectives
Describe the pathophysiology and management of shock.
Global Objectives
At the completion of this problem, students should be able to define sepsis and describe the pathophysiology of septic shock. They should be able to identify the diagnostic work up and management of someone with sepsis and articulate the process of antimicrobial selection in such cases.
Part 5
Integration Foundation
Host Defense and Neoplasia
Week 1
Providing anti-oppressive health care
Health and the Climate Crisis
Hypotension/Shock
Concepts of Health and Its Determinants
Fever and Hyperthermia

Tutorial: Ethel MacConkey IF Host Defence and Neoplasia

Integration Foundation, Host Defense and Neoplasia, Week 1

Ethel is a 76 year old widow. She has a history of hypertension (treated with a thiazide diuretic and a calcium channel blocker), hyperlipidemia (treated with an HMGCoA reductase inhibitor), and obesity. Apart from this, she has been relatively healthy, and plays an active role with her 3 grandchildren as well as her church. Unfortunately, over the past few years, she has had increasing difficulty walking because of pain from osteoarthritis in her hips (especially her right hip) and, to a lesser extent, her knees. She therefore undergoes a right total hip arthroplasty. After 6 days in hospital, she is transferred to the rehab ward for further physiotherapy to improve her mobility. Five weeks into her rehab stay she develops a fever of 38.7 C. Additionally her physiotherapist has noticed that over the past 7-8 days Ethel has been less willing to participate in her exercises due to complaints of pain in her right hip. Concerned about Ethel's fever, the nurses give her acetaminophen and call the attending physiatrist to assess the patient for a potential infectious source.

General Objectives
Describe the normal flora at the most important non-sterile sites in the body.
Describe the differences between and classify various types of pathogens (e.g. bacteria, viruses, fungi and parasites).
Describe the role of infection control in preventing the acquisition and spread of infectious diseases.
Global Objectives
Upon completion of this problem, students will be able to explain how skin forms an integral component of the immune system and the consequences of breaches in this barrier. They will be able to describe the composition of normal host flora, the classification of bacteria and explain how these bacteria can lead to infections, such as those at surgical sites, especially when facilitated by the presence of prosthetic material.
Integration Foundation
Host Defense and Neoplasia
Week 1
Skin and Integument Conditions
Frailty in the Elderly
Oligoarthralgia (Pain in One to Four Joints)
Fever in the Immune Compromised Host / Recurrent Fever
Skin Wounds

Tutorial: Melissa Wang IF Host Defence and Neoplasia

Part 5, Integration Foundation, Host Defense and Neoplasia, Week 1

Melissa is a 35-year-old mother of three who works in marketing. She is being seen in consultation by the Internal Medicine service while admitted to Thoracic Surgery for an empyema. Three months prior she began to have cough with intermittent fevers and chills. She has been treated as an outpatient by her family doctor with Amoxicillin, Azithromycin and Levofloxacin over this time. Her symptoms would initially improve but would return within days of completing her antibiotic course. Her condition continued to worsen until this admission. On review of her past history, she has chronic facial pain and pressure with frequent purulent discharge, and typically has 2-3 sinus infections per year requiring antibiotics. She has never had pneumonia before this year. She has never received pneumococcal vaccination. She received her childhood immunization series and had her last tetanus and diphtheria booster 4 years ago. She has been re-vaccinated for measles, mumps, rubella twice, after prenatal evaluation deemed her non-immune. Prior to onset of these symptoms, her only medication was the oral contraceptive pill. In addition to leaving recommendations to manage her empyema, you wonder about her history of recurrent sinusitis and recent pneumonias. As such, you order some screening bloodwork.

General Objectives
Describe the differences between and classify various types of pathogens (e.g. bacteria, viruses, fungi and parasites).
Describe diagnosis and treatment considerations for common chronic diseases.
Explain the overall structure of the immune system.
Describe the infections that patients with common forms of immunodeficiency are at risk of acquiring.
Global Objectives
Upon completion of this problem, students will be able to integrate the various branches of the immune system and be able to identify when to initiate an immunodeficiency work-up.
Part 5
Integration Foundation
Host Defense and Neoplasia
Week 1
Pleural Effusion
Fever in the Immune Compromised Host / Recurrent Fever
Concepts of Health and Its Determinants

Tutorial: P.J. Peters (Part 1) IF Host Defence and Neoplasia

Part 5, Integration Foundation, Host Defense and Neoplasia, Week 2

As you head off to lunch after wrapping up your morning clinic, you peruse your afternoon schedule and note that the first patient is someone you have not seen in three years. You therefore grab his chart to review his history. P.J. Peters is a 34-year-old male who immigrated from Uganda 10 years ago. Four years ago, he presented with a dry cough and mild shortness of breath. Given that you had noted a few crackles in his lower lungs bilaterally, you had prescribed him antibiotics for pneumonia. In spite, of therapy his symptoms progressed over a 2-3 week period and he landed in the emergency. A chest x-ray at the time revealed a bilateral interstitial infiltrate. Due to progressive hypoxia he underwent a bronchoalveolar lavage which revealed he had pneumocystis jiroveci pneumonia (PJP or PCP). This raised the suspicion of underlying HIV and his serology was sent off and came back positive. On further questioning, he admitted to a 2 year period in his life in his early 20s where he had unprotected sex with multiple partners.

General Objectives
Explain the overall structure of the immune system.
Recognize how an interdisciplinary team can help manage a patient with complex chronic disease.
Identify a patient centered approach to care for individuals with chronic illnesses.
Global Objectives
Upon completion of this problem, students should be able to describe the pathogenesis and progression of HIV infection and the role the virus plays in causing long-term immunosuppression. Students will be able to describe how long-term immunosuppression can result in opportunistic infections.
Part 5
Integration Foundation
Host Defense and Neoplasia
Week 2
Cough
Cyanosis, Hypoxia
Dyspnea

Tutorial: P.J. Peters (Part 2) IF Host Defence and Neoplasia

Part 5, Integration Foundation, Host Defense and Neoplasia, Week 2

When you see Mr. Peters next, you learn that he had continued to take his HAART faithfully an additional 6 months after he last saw you. He had been feeling physically well and figured his virus was under control (as he recalled it had last been "non-detectable") and so began questioning the need to continue his medications. He was concerned about long-term side effects of therapy and figured he could diminish his risk by reducing his exposure to HAART. Moreover he had started a new job around that time and did not want anyone to inadvertently find out about his diagnosis of HIV. He therefore elected to stop taking his anti-retrovirals. Mr. Peters was reluctant to tell his physicians about his decision and so he had not come back for his follow ups. He returns today complaining of a new painful rash on his chest that appeared 2 days prior. Additionally he notes a 3-month history of increasing fatigue as well as intermittent fevers, night sweats and a 20 lb weight loss. On examination his temperature is 37.2º C, blood pressure 135/80, pulse 79. There are 2 cm nodes palpable in the cervical and axillary areas bilaterally. His throat is clear. When you examine his chest you notice a vesicular rash over the right side of his chest extending from the midline towards his right axilla at the level of his nipple. Examination of his respiratory and cardiovascular system are unremarkable. His abdomen is soft with no palpable masses or organomegaly. Examination of his extremities is unremarkable.

General Objectives
Explain the overall structure of the immune system.
Recognize how an interdisciplinary team can help manage a patient with complex chronic disease.
Identify a patient centered approach to care for individuals with chronic illnesses.
Global Objectives
Upon completion of this problem, students should be able to describe how long-term immunosuppression can result in opportunistic infection and increase the risk of developing malignancy.
Part 5
Integration Foundation
Host Defense and Neoplasia
Week 2
Fatigue
Skin and Integument Conditions
Lymphadenopathy
Fever in the Immune Compromised Host / Recurrent Fever
Weight Loss / Eating Disorders / Anorexia

Tutorial: Grace Tran IF Host Defence and Neoplasia

Part 5, Integration Foundation, Host Defense and Neoplasia, Week 3

Grace is a 50-year-old woman working full-time and busy with her family. She has been feeling exhausted lately and feels like she may have had fevers on and off. She is having difficulty finding the energy to coach her daughter's early-morning hockey games. At the urging of her partner, she sees her family physician who notes that she is afebrile with mild dyspnea and a cough, having faint crackles on the right side of her chest. Suspecting pneumonia, her physician sends Grace for a chest x-ray and she is given an antibiotic prescription to treat community-acquired pneumonia. The x-ray report described a density in the right lower lung zone, and Grace starts her medication with follow up in 3 weeks. When she returns, she mentions that she finished the course of antibiotics but that they “did nothing” and that she feels a bit worse actually. Her exam is unchanged, but given that she has a 30 pack-year smoking history, her physician orders a repeat chest x-ray. This shows mild interval growth of the original opacity. This time, the radiologist states that the area is suspicious for possible malignancy. On further history, Grace was treated for Hodgkin's lymphoma at the age of 18, for which she received 3 cycles of ABVD chemotherapy followed by radiation to the mediastinal lymph nodes. She has been “cancer free” and completely well since, so much so that she stopped going to her AfterCare follow-up appointments. Grace grew up in a middle-class suburban neighbourhood and completed a geosciences degree at a local university. She has spent the last 20 years working for a mining company evaluating many different ore samples. She frequently deals with silica ores and metal-based ores, including iron, nickel, chromium, zinc and aluminum. She wears an N95 dust mask when handling the samples. Grace comes from a family of heavy smokers. Grace's father died 5 years ago from bladder cancer. Her paternal uncle, also a smoker and a heavy consumer of alcohol, had previously died of a throat cancer. Her older sister, yet another smoker, had cancer of the cervix treated successfully with radiotherapy. Due to the x-ray findings, Grace is sent for a CT scan of her chest. This confirms a 2.5 cm lesion in the central right lower lobe well away from the chest wall and the hilum.

General Objectives
Explain modifiable and non-modifiable causes of cancer.
Global Objectives
Upon completion of this problem, the student should be able to describe how tobacco and radiation exposure can result in carcinogenesis. Students should be able to describe the value of identifying occupational exposures to carcinogens at the individual, workplace, and community levels.
Part 5
Integration Foundation
Host Defense and Neoplasia
Week 3
Fatigue
Fever in the Immune Compromised Host / Recurrent Fever
Environment
Work-Related Health Issues

Tutorial: Philippe LaCologne IF Host Defence and Neoplasia

Part 5, Integration Foundation, Host Defense and Neoplasia, Week 3

Mr. Lacologne is a 41 year old man who had a stage II colon cancer resected 3 years prior. He had his annual CT scan, and there was a 3 cm hypoechoic lesion in segment 6. His surgeon referred him to a liver Surgeon and Medical Oncologist. The surgeon explained that this is likely recurrent disease from his colon cancer, and recommended chemotherapy neo-adjuvantly and after surgery. He was started on FOLFOX chemotherapy for 6 cycles, subsequent CT and MRI of his liver showed a partial response to chemotherapy. He underwent a left hepatic lobectomy, and following recovery completed an additional 6 cycles of FOLFOX. Two years later subsequent lung lesions are identified in multiple lobes bilaterally. He returns to the Medical Oncologist, and is recommended to start chemotherapy (FOLFIRI/bevacizumab). He asks why surgery is not an option now, and said he heard on the internet that that this bevacizumab drug can cure cancer.

General Objectives
Recognize how an interdisciplinary team can help manage a patient with complex chronic disease.
Identify a patient centered approach to care for individuals with chronic illnesses.
Describe the role of surgery, radiation and systemic therapy in the management of cancer.
Global Objectives
Upon completion of this problem, students should be able to discuss the role of adjuvant chemotherapy and surveillance in at risk patients after surgery. Students will describe the metastatic cascade and explain why some cancers metastasize preferentially to certain sites.
Part 5
Integration Foundation
Host Defense and Neoplasia
Week 3

Tutorial: McFadden Family IF Maternal and Child Health Risks

Part 5, Integration Foundation, Maternal Health Risks/Aging-Related Care, Week 1

Claire brings infant Marie to her family physician for the 2-month well baby visit, alone. When asked how she and Dave are adjusting, she mumbles “fine.” Marie has been “fussy” during the night, and Claire is finding breast-feeding to be a challenge. Newborn examination is performed, the Rourke baby record is completed and no concerns noted. Claire is motivated to breastfeed but she says Dave thinks formula is better and is worried the baby is not getting enough milk and that is why she is crying. “He says it is my fault.” The benefits of nursing to mom and baby are reviewed, along with formula options, and a referral to a lactation consultant is made. Two weeks later, the office receives an “urgent” call from Claire’s aunt asking that she be seen. Notably, Claire did not bring in baby Marie for a follow-up, in spite of a reminder call from the office. Claire is booked as the last appointment of the afternoon, and reception staff comment they heard screaming in the background while Claire’s aunt made the call. One receptionist says “things are not right” in the McFadden family.

General Objectives
Identify and describe the risks of intimate partner violence, and the obligations of the healthcare team in assessment and management of a family at risk.
Identify some of the main risks for child maltreatment and explain when to involve child protection professionals.
Explain the impact of adverse childhood experiences on lifelong health and opportunity and discuss strategies to mitigate the impact of such adverse experiences.
Global Objectives
Upon completion of this problem, students should be able to identify and describe the risks of intimate partner violence, and the obligations of the healthcare team in the assessment and management of a family at risk.
Part 5
Integration Foundation
Maternal Health Risks/Aging-Related Care
Week 1
The Well Child and Adolescent
Headache
Periodic health encounter/Preventive health advice
Adult Abuse / Intimate Partner Abuse
Immunization
Newborn Assessment

Tutorial: Claire McFadden Part 2 IF Maternal and Child Health Risks

Part 5, Integration Foundation, Maternal Health Risks/Aging-Related Care, Week 1

Claire is a 35-year-old G1 with Type 1 DM. She had an episode of pyelonephritis at 26 weeks gestation and did well following this, and was last seen at 30 weeks. At 32 weeks Claire presents in St. Catharines with a headache and RUQ pain. Her husband says that Claire’s swelling, especially in her face, has worsened over the past 2 days. BP is 160/105. FH is normal. She has 4+ urine protein. Hb 142 g/L, platelets 152, AST 67, ALT 75, INR/PTT normal, fibrinogen 5.8 g/L, glucose 6.5 mM/L, creatinine 100 uM, urea 4.2 mM. Urinary ketones are negative. She is given morphine and oral labetalol. Her symptoms settle and BP is 145/95. Ultrasound shows a cephalic fetus with normal head and femur measurements but the abdominal measurement lags by 3 weeks. There is marked oligohydramnios. Doppler studies are abnormal. MUMC is called and a decision is made to transfer Claire. On arrival, she complains of severe RUQ pain. BP is 170/110. She has made very little urine and it is dark tea coloured. Hb 137 g/L, platelets 100, AST 265, ALT 310. Her urinary protein to creatinine ratio is 500 mg/mmol. She is given a dose of nifedipine and MgSO4 is started. A decision is made to do an immediate C/S with spinal.

General Objectives
Describe maternal complications of pregnancy.
Global Objectives
Upon completion of this problem, students should be able to identify maternal complications of pregnancy with an emphasis on hypertension, and describe resuscitative measures used in hypertensive emergencies (eclampsia). Students should be able to describe the significance of neonatal hypoglycemia and explain the principles surrounding newborn screening for inborn errors of metabolism.
Part 5
Integration Foundation
Maternal Health Risks/Aging-Related Care
Week 1
Proteinuria
Acute Kidney Injury (Anuria or Oliguria)
Generalized Edema
Intrauterine Growth Restriction
Prenatal Care
Intrapartum and Postpartum Care
Hypertensive Disorders of Pregnancy

Tutorial: Susanna Green Part 2 IF Chronicity and Complexity

Part 5, Integration Foundation, Complexity and Chronicity, Week 3

Susanna is an Indigenous woman who lives in the Six Nations of the Grand River Reserve. She is well-known to you. She first met you in the outpatient setting during your day in family medicine rotation two years ago at the beginning of medical school. At that time, Susanna had several issues with the management of diabetes, including regular blood glucose monitoring and appropriate medical management. Susanna has a complex medical history including type 2 diabetes, hypertension, obstructive sleep apnea, and a previous myocardial infarction and subsequent triple coronary bypass graft. After a lengthy stay in ICU six months ago due to pneumonia and septic shock, she developed end stage renal disease and is currently receiving in centre hemodialysis through a tunneled internal jugular catheter twice weekly. You are currently on your clerkship selective on nephrology with Susanna assigned to your team. Susanna has been admitted for a worsening chronic wound on her right heel. Susanna states she was attending the Grand River dialysis outpatient clinic on the Six Nations reserve 2 days ago, when one of the nurses there noticed increasing drainage from her right heel wound. Susanna’s vital signs there revealed she was febrile at 38.1 degrees and tachycardiac at 110 beats per minute with blood pressure 90/50 mmHg, respiratory rate 17 breaths per minute, and oxygen 100% on room air. Bloodwork was then taken, and a septic workup was also ordered.

General Objectives
Describe the prevalence of chronic disease in Canada and factors which contribute to it.
Describe diagnosis and treatment considerations for common chronic diseases.
Recognize how an interdisciplinary team can help manage a patient with complex chronic disease.
Identify a patient centered approach to care for individuals with chronic illnesses.
Global Objectives
Upon completion of this problem, students should be able to discuss the assessment and management of the microvascular and macrovascular complications of diabetes. Students should be able to recognize the importance of an interdisciplinary team to manage complications of diabetes.
Part 5
Integration Foundation
Complexity and Chronicity
Week 3
Providing anti-oppressive health care
Indigenous Health
Diabetes Mellitus
Hypertension
Chronic Kidney Injury
Skin Wounds

Tutorial: Hannah Rosen Part 2 IF Chronicity and Complexity

Part 5, Integration Foundation, Complexity and Chronicity, Week 4

Hannah Rosen is 18-year-old female who presents to the outpatient clinic after a frantic call to the receptionist earlier during the day. Hannah has been coming to the clinic for the past 16 years for treatment and monitoring of her cystic fibrosis. Her parents, who have been supportive, are out of town on an anniversary cruise and Hannah didn’t know who to call. Hannah states she has been having increased sputum production, low grade fever and difficulty catching her breath over the past few days. She took the action plan of ciprofloxacin she has at home. She takes this when her respiratory symptoms worsen. Hannah states she has been compliant with her antibiotics, but her symptoms suddenly got worse overnight. Hannah does not want her parents to know about this and asks that they not be contacted about her hospital visit. On examination, Hannah appears in distress. She is using her intercostal muscles to help her breathe and appears cyanotic and diaphoretic. Her vitals are taken by the clinic nurse while they are waiting for her pediatric respirologist to finish with the previous patient. Hannah’s temperature is 39.1, oxygen saturation is 91 percent, heart rate is 115 and her blood pressure is 100/60. The nurse calls for immediate help and Hannah is taken to the ICU where she is placed on oxygen. Chest x-ray and additional blood work including ABGs are ordered.

General Objectives
Describe the medical and ethical principles of organ transplantation and living and deceased donation.
Global Objectives
Upon completion of this problem, students should be able to describe the pathophysiology of chronic respiratory failure and associated clinical decision-making with regard to organ transplantation and donation.
Part 5
Integration Foundation
Complexity and Chronicity
Week 4
Cyanosis, Hypoxia
The Dying Patient

Clinical Skills Sessions: Headache and Cough in a Pregnant Patient x 3 days

Transition to Clerkship, Week 2

You are working with a community family physician who works in their clinic and the emergency department at an academic centre in St. Catharines. You are early in your clerkship and haven’t completed your Obstetrics/Gynecology core rotation yet. The clinic is able to do in-house ECGs and Urine dipsticks. They can send a requisition for bloodwork and chest x-ray, completed offsite. Your first patient is Vanessa, a 35 year-old G2P0 patient who is 28 weeks pregnant with exercise-induced asthma and normal prenatal course to date, last seen for prenatal care at 24-weeks where she was sent for a gestational diabetes screen that was normal. She is taking a prenatal vitamin with 1mg folic acid daily. Your clinic is following her for prenatal care within a shared care model for her pregnancy, with an obstetrician in St. Catharines following her with a plan to deliver at Niagara Health St. Catharines hospital. You were due to see her in follow-up later this week (for her 28-week visit) but she has been scheduled as an urgent visit today for headache and cough x 3 days.

Activity Objectives
Learn and practice the SBAR (Situation, Background, Assessment, Recommendation) tool for verbal handover of patient care.
Learn and to practice the SOAP (Subjective, Objective, Assessment, Plan) tool for written handover of patient care.
Practice holding a goals of care discussion with a capable patient using the Serious Illness Conversation Guide framework.
Practice communicating serious illness news to a substitute decision maker over the phone.
Review routine prenatal care visits, including questions to ask at each visit in the 3rd trimester.
Practice a focused history and exam for a patient presenting with abnormal vital signs, with a focus on infection.
Review intermittent auscultation as an in-office assessment of fetal well-being, including normal vs. abnormal findings.
To discuss initial in-office management for a patient who is clinically unstable, including transfer to acute care.
Transition to Clerkship
Week 2
Allergic Reactions and Atopy
Cough
Headache
Prenatal Care

Clinical Exposure: EM Medical Expert (presenting problems)

Clerkship, Emergency Medicine Rotation

Demonstrate an approach to patients presenting to the ED with the following problems listed below (including basic differential diagnosis, initial investigations, and initial treatments)

Clerkship Objectives
Chest pain
Shortness of breath
Altered level of consciousness - including the recognition and management of acute stroke
Anaphylaxis / severe allergic reaction
Abdominal pain
Loss of consciousness (syncope)
Shock - Recognize shock and predict underlying etiology (distributive, cardiogenic, hypovolemic, obstructive).
Seizure
Cardiorespiratory arrest
Headache
Minor trauma / MSK injuries (including fracture / dislocation/ sprain). Explain the ABCDE approach to major and minor trauma, identify resuscitative priorities and recognize injuries which require acute management.
Abnormal behavior (psychosis, delirium, intoxication, violence).
Head injury - minor
Fever
Dizziness / vertigo
Cardiac dysrhythmias. Synthesize ACLS (Advanced Cardiovascular Life Support) algorithms, recognize unstable ACLS states and use ACLS algorithms to guide treatment.
Vaginal bleeding - pregnant
Poisoning
Burns - minor / major
Urinary symptoms
Neck and back pain
Eye pain (including red eye)
Clerkship
Emergency Medicine Rotation
Lower urinary tract symptoms
Allergic Reactions and Atopy
Back Pain and Related Symptoms (e.g., Sciatica)
Neck Pain
Burns
Cardiac Arrest
Chest Pain
Dizziness, Vertigo
Dyspnea
Eye Redness
Headache
Poisoning
Early Pregnancy Loss / Spontaneous Abortion
Psychosis
Seizures / Epilepsy
Syncope and Pre-Syncope
Trauma
Vaginal Bleeding, Excessive/Irregular/Abnormal
Abnormal Heart Sounds and Murmurs
Acute Abdominal Pain
Delirium
Dysuria, Urinary Frequency and Urgency, and/or Pyuria
Fever in the Immune Compromised Host / Recurrent Fever
Hypotension/Shock
Abdominal Pain (Children)
Bone or Joint Injury
Chronic Abdominal Pain
Fever and Hyperthermia
Head Trauma / Brain Death / Transplant Donations

e-Learning Module: Anaphylaxis

Clerkship, Emergency Medicine Rotation

Be able to identify and define anaphylaxis. Know how to manage a patient with an acute anaphylactic reaction in the Emergency Depatment.

Clerkship Objectives
Anaphylaxis / severe allergic reaction
Clerkship
Emergency Medicine Rotation
Allergic Reactions and Atopy
Dyspnea
Urticaria, Angioedema

e-Learning Module: Family Medicine Pediatric Case

Clerkship, Family Medicine Rotation

Be familiar with Growth and Development Milestones and know how to determine if the child needs early interventions (Rourke, Nippissing). Nippissing has a new name Looksee. Describe the impact the social determinants of health have on health outcomes (young, single mother with little money and time to raise child). Appreciate the role of the Family Physician as an advocate for health - what resources can you leverage in the community to help optimize life for both Ashley and her mother? Be able to discuss contraception planning to prevent another unplanned pregnancy. Be familiar with common skin rashes in children

Clerkship Objectives
Well baby / Well child
Clerkship
Family Medicine Rotation
The Well Child and Adolescent
Contraception
Skin and Integument Conditions
Periodic health encounter/Preventive health advice
Immunization
Failure To Thrive (Infant, Child)
Concepts of Health and Its Determinants
Essential Clinical Experience
Well baby / Well Child
Clerkship
Family Medicine Rotation
Periodic health encounter/Preventive health advice
Immunization
Newborn Assessment

Tutorial: Periodic Health Review

Clerkship, Family Medicine Rotation

Clerkship Objectives
Preventative health care female
Preventative health care male
Well baby / Well child
Clerkship
Family Medicine Rotation
Periodic health encounter/Preventive health advice
Immunization

Clinical Exposure: HIV infection

Clerkship, Internal Medicine Rotation

Clerkship Objectives
Sexually transmitted diseases including HIV infection.
Clerkship
Internal Medicine Rotation
Fever in the Immune Compromised Host / Recurrent Fever

Clinical Exposure: Fever

Clerkship, Internal Medicine Rotation

Clerkship Objectives
Fever
Clerkship
Internal Medicine Rotation
Fever in the Immune Compromised Host / Recurrent Fever
Fever and Hyperthermia

Self-Assessment Quiz: Isoimmunization

Clerkship, Obstetrics and Gynecology Rotation

Framework Objectives
Red blood cell antigens
Use of immunoglobulin prophylaxis during pregnancy
Clinical circumstances under which D isoimmunization is likely to occur
Methods used to determine maternal isoimmunization and severity of fetal involvement
Clerkship
Obstetrics and Gynecology Rotation
Prenatal Care
Intrapartum and Postpartum Care

e-Learning Module: Isoimmunization

Clerkship, Obstetrics and Gynecology Rotation

Framework Objectives
Red blood cell antigens
Use of immunoglobulin prophylaxis during pregnancy
Clinical circumstances under which D isoimmunization is likely to occur
Methods used to determine maternal isoimmunization and severity of fetal involvement
Clerkship
Obstetrics and Gynecology Rotation
Prenatal Care
Intrapartum and Postpartum Care
Clerkship Objectives
Describe the differential diagnosis of a patient having postoperative fever. For each entity, discuss the clinical manifestations, appropriate diagnostic work-up, and management: Within 24 hours: response to surgical trauma; atelectasis; necrotizing wound infections. Between 24 and 72 hours: pulmonary disorders (atelectasis, pneumonia); catheter related complications (IV-phlebitis, Foley-UTI). After 72 hours: infectious (UTI, pneumonia, wound infection, deep abscess, anastomotic leak, prosthetic infection, parotitis); noninfectious (deep vein thrombosis).
Clerkship
Surgery Rotation
Fever in the Immune Compromised Host / Recurrent Fever
Essential Clinical Experience
Fever in postoperative patient
Surgery Rotation
Fever in the Immune Compromised Host / Recurrent Fever

Concept Integration and Review: Obstetrics

Post-clerkship, Concept Integration and Review, Week 1

To review aspects of Obstetrics relevant to the LMCC exam. Clinical pearls for clinical practice. Clinical epidemiology.

Post-clerkship
Concept Integration and Review
Week 1
Early Pregnancy Loss / Spontaneous Abortion
Preterm Labour
Intrauterine Growth Restriction
Prenatal Care
Intrapartum and Postpartum Care
Hypertensive Disorders of Pregnancy