Recognize the antigen-specific nature of T and B cells. Understand the importance of antigen processing/MHC molecules. Understand the importance of CD4 T “helper” cells in influencing the nature of the immune response. Understand the cytotoxic nature of CD8 T cells. Understand the concepts of central and peripheral tolerance. Discuss Gel-Coombs classification of “hypersensitivity” reactions. Discuss specific examples of autoimmune diseases. Discuss modes of treatment for autoimmune diseases.