Objectives

• What is a tumour suppressor gene?
• What is a predictive versus a prognostic factor?
• How is radiation used to treat cancers?
• Basic mechanisms of cellular transformation and the characteristics of malignant cells.
• The evolution of clonal populations of genetically abnormal cells, and the types of genes and mutations which cause malignancy.
• Examples of genetic pathways of mutation causing cancers to develop, such as CML, retinoblastoma, hereditary breast & ovarian cancer, colorectal cancer.
• How to distinguish sporadic cancers from hereditary cancers, and current practices in genetic counseling and clinical management of people at increased risk for hereditary cancers.
• Describe how sporadic and hereditary cancers arise from normal tissues.
• Distinguish sporadic and hereditary presentations of cancer.
• Understand how the characterization of molecular changes in cancers and tumours can lead to the development of targeted therapies and improve treatment outcomes.
• Explain the risks, benefits and limitation of genetic testing for hereditary cancer.

Tags

Archived Diagnosis Ethics Genetics Prevention and control Prognosis 2010 Genetics Medical Oncology Neoplastic Syndromes, Hereditary [C04.700] Breast Neoplasms [C04.588.180] Cell Cycle [G04.299.134] Colonic Neoplasms [C04.588.274.476.411.307.180] Cytogenetics [H01.158.273.343.180] Ethics [K01.752.566.479] Genetic Counseling [N02.421.308.400] Genetic Testing [N02.421.308.430] Germ-Line Mutation [G05.365.590.350] Oncogenes [G05.360.340.024.340.375.500] Pharmacogenetics [H01.158.703.052] Retinoblastoma [C04.557.465.625.600.725] Somatic Hypermutation, Immunoglobulin [G05.355.600.810]