Review the role of opioids in the brain and the signs and symptoms of withdrawal. Learn how to identify patients with opioid use disorder and review the various management options including how to manage patients in primary care with opioid agonist therapy with buprenorphine. Educate patients on strategies to prevent opioid overdose including the use of naloxone, a vital tool for overdose prevention. This should be completed by the end of MF4.