Part 1: You are working in the Red Blood Cell Disorders Clinic at McMaster. You are asked to see Ms. LW by your preceptor for routine follow up. Ms. LW is a 43-year-old cisgender woman who was diagnosed with sickle cell disease as a child while living in Guyana. Part 2: It is a few months later and you are on a rotation working in the emergency department. You see Ms. LW’s name on the tracker and remember seeing her in the RBC Disorders Clinic. You pull the triage assessment and read that Ms. LW is presenting with a 2-day history of jaundice and pain in her arms and back, which has been unresponsive to oral hydromorphone at home. Vitals in triage reveal HR 110, BP 110/65, T 36°C, RR 16, SpO2 99% on room air.