You are on elective at a Health Clinic in downtown Hamilton with a multicultural patient population. Your supervisor asks you to see Alexandria Vardalos. Alexandria is an 8-month-old baby girl who is brought in by her parents. She was healthy at birth, but over the last 2 months, she has not been growing as fast as her sister did at the same age. She is frequently irritable and has difficulty feeding. On physical examination, Alexandria is pale, but in no apparent distress. She is afebrile with HR 125, RR 45, BP 90/60 mmHg and oxygen saturation 98% on room air. She is at the 5th percentile for both weight and height. When you palpate her abdomen, you notice that she has an enlarged liver and spleen. Her peripheral blood smear shows microcytosis, hypochromia and poikilocytosis. Hemoglobin electrophoresis shows Hb F 99.2%, Hb A2 0.8%, Hb A 0%. You inform the parents that their baby appears to be anemic and may have an inherited blood disorder. Her mother states: ‘I’m anemic – I inherited it from my mother and her family back in India. I didn’t think our children would get this because my husband’s family is Greek.”