Awat Khali MF3 Endocrinology
Activity
Tutorial
Tutorial
Awat Khali, a 3.2 kg female infant, is born to a 28 year old mother at 41 weeks gestation. The family is Muslim and has recently immigrated from the Kurdish region of Turkey. Her parents are first cousins. Each parent has numerous brothers and sisters and most have already had children. Everybody is reported as healthy and well.
At delivery the child is noted to have atypical genital development. The clitoris is prominent, length being approximately 1.5 cm. There is posterior fusion of the labia.
Curriculum Block
Endocrinology / Medical Foundation 3 / Part 3 / Week 3
- Indicates most relevant
Objectives
General Objectives
- Describe the embryology and physiology of sexual differentiation and explain the possible mechanisms involved in the presentation of ambiguous genitalia.
- Explain the impact of mutations of the androgen receptor on sexual phenotype.
Global Objectives
Assessments
End-Unit Tutorial Assessment
Concept Application Exercise (CAE)
Tags
Basic Sciences
Anatomy
Biochemistry
Embryology
Genetics
Human development
Physiology
Reproduction
Curriculum Block
Endocrinology
Medical Foundation 3
Part 3
Week 3
Curriculum Week
Part 3
Week 7
Discipline
Endocrinology
Genetics
Pediatrics
Urology
Longitudinal Discipline
Genetics
MCC Presentations
Congenital Anomalies, Dysmorphic Features
Genetic Concerns
McMaster Program Competencies
1.7 Counsel and educate patients and their families to empower them to participate in their care and enable shared decision-making
2.2 Apply biomedical scientific principles fundamental to health care for patients and populations.
MeSH
Androgen-Insensitivity Syndrome [C13.351.875.842.316.627.109]
Congenital Abnormalities [C16.131]
Dihydrotestosterone [D04.808.054.040.248]
Disorders of Sex Development [C12.706.316]
Disorders of Sex Development [C16.131.939.316]
Emigrants and Immigrants [M01.189]
Gender Identity [F01.393.446.250]
Genes, X-Linked [G05.420.457]
Genitalia [A05.360]
Ovotesticular Disorders of Sex Development [C16.131.939.316.343]
Pediatrics [H02.403.670]
Receptors, Androgen [D12.776.930.682.150]
Reproductive Physiological Phenomena [G08.686]
Sex Determination (Genetics) [G05.355.865]
Sex Differentiation Disorders [C19.391.775]
Sex Differentiation [G07.345.500.325.377.843]
Sexual Development [G08.686.841]
Social Work [N02.421.849]
Testosterone [D06.472.334.851.968.984]
Urogenital Abnormalities [C16.131.939]
