Physicians tend to focus on diagnosis and treatment, while patients care about etiology - "why did this happen to me?" and prognosis - "what will this mean for me?" The evidence around diagnosis and treatment is clearer to collect, evaluate and summarize; gathering the evidence around prognosis, and translating it to apply and communicate it to a particular patient is much trickier. We hope this session will help you to: Answer patients' questions about "What does this mean to me?" (prognosis); Realize that even with evidence there is uncertainty but that information still needs to be communicated; Understand that physicians play a supportive role in interpreting test results, planning the future and monitoring symptoms.